{"doi":"10.1245/s10434-024-15893-7","title":"Survival Outcomes in Patients with Resectable Gastric Cancer Treated with Total Neoadjuvant Therapy","abstract":null,"journal":"Annals of Surgical Oncology","year":2024,"id":638641,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":902066,"name":"Yuki Hirata","orcid":"0000-0002-0283-6392","position":1,"is_corresponding":false},{"id":69924,"name":"Jaffer A. Ajani","orcid":"0000-0001-9946-0629","position":2,"is_corresponding":false},{"id":474412,"name":"Mariela Blum Murphy","orcid":null,"position":3,"is_corresponding":false},{"id":1658935,"name":"Jenny J. Li","orcid":null,"position":4,"is_corresponding":false},{"id":1381717,"name":"Prajnan Das","orcid":"0000-0002-8253-4190","position":5,"is_corresponding":false},{"id":72433,"name":"Bruce D. Minsky","orcid":"0000-0001-8434-7930","position":6,"is_corresponding":false},{"id":401342,"name":"Paul F. Mansfield","orcid":null,"position":7,"is_corresponding":false},{"id":341840,"name":"Naruhiko Ikoma","orcid":"0000-0002-9825-9234","position":8,"is_corresponding":false},{"id":341839,"name":"Brian D. Badgwell","orcid":"0000-0002-9915-8355","position":9,"is_corresponding":false},{"id":186572,"name":"Yun Song","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Survival Outcomes in Patients with Resectable Gastric Cancer Treated with Total Neoadjuvant Therapy","abstract":"<h4>Background</h4>Perioperative chemotherapy has become the standard of care for locally advanced gastric cancer. Total neoadjuvant therapy (TNT), including both chemotherapy and chemoradiation, is utilized in other gastrointestinal malignancies. We determined survival in a contemporary cohort of gastric cancer patients treated with TNT.<h4>Methods</h4>Using a prospective institutional database, patients diagnosed with cT2-4 or cN+ gastric adenocarcinoma (January 2012 to June 2022) who underwent staging laparoscopy, received TNT, and underwent gastrectomy were identified. Overall survival (OS) and disease-specific survival (DSS) were determined using standard statistical methods.<h4>Results</h4>The study included 203 patients. The most common TNT sequence was induction chemotherapy followed by chemoradiation (n = 186 [91.6%]). A total of 195 (96.1%) patients completed planned neoadjuvant treatments. Surgery included total gastrectomy in 108 (53.2%), extended (D1+/D2) lymphadenectomy in 193 (95.1%), and adjacent organ resection in 19 (9.4%) patients. Pathologic complete response (pCR) was achieved in 32 (15.8%) patients. The 5-year OS rate was 65.2% (95% confidence interval [CI] 57.8-73.5%), and the 5-year DSS rate was 70.8% (95% CI 63.6-78.9%) in the study cohort. Among patients with pCR, the 5-year OS rate was 89.1% (95% CI 78.1-100.0%), and the 5-year DSS rate was 96.9% (95% CI 91-100%). Posttreatment pathologic N and M stages were the strongest prognostic indicators associated with both OS and DSS.<h4>Conclusions</h4>Total neoadjuvant therapy for resectable gastric cancer is associated with a high rate of treatment completion and promising survival outcomes. Prospective comparisons with perioperative treatment are needed to identify patients most likely to benefit from TNT.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39048909","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Holly Clegg Gastric Cancer Research Fund","grant_id":"","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1245/s10434-024-15893-7.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1245/s10434-024-15893-7/fulltext.html","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Adenocarcinoma","Stomach Neoplasms","Antineoplastic Combined Chemotherapy Protocols","Prognosis","Neoadjuvant Therapy","Gastrectomy","Lymph Node Excision","Survival Rate","Follow-Up Studies","Prospective Studies","Adult","Aged","Middle Aged","Female","Male","Chemoradiotherapy","Induction Chemotherapy"],"keywords":["Gastric cancer","Neoadjuvant chemotherapy","Neoadjuvant Chemoradiation","Gastric Cancer Survival","Gastroesophageal Junction Cancer","Total Neoadjuvant Therapy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T21:04:20.566130Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}