{"doi":"10.1245/aso.2003.08.004","title":"Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Intraoperative Chemotherapy for Peritoneal Carcinomatosis Arising From Colon Adenocarcinoma","abstract":null,"journal":"Annals of Surgical Oncology","year":2003,"id":652442,"datarank":0.7289718606542509,"base_score":4.859812404361672,"endowment":4.859812404361672,"self_citation_contribution":0.7289718606542509,"citation_network_contribution":0.0,"self_endowment_contribution":0.7289718606542509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":128,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1506792,"name":"Simone Mocellin","orcid":null,"position":1,"is_corresponding":false},{"id":1157432,"name":"Carlo Riccardo Rossi","orcid":"0000-0001-7875-5655","position":2,"is_corresponding":false},{"id":1701990,"name":"Mirto Foletto","orcid":null,"position":3,"is_corresponding":false},{"id":1506791,"name":"Luca Campana","orcid":null,"position":4,"is_corresponding":false},{"id":179538,"name":"Donato Nitti","orcid":null,"position":5,"is_corresponding":false},{"id":179536,"name":"Mario Lise","orcid":null,"position":6,"is_corresponding":false},{"id":1701989,"name":"Pierluigi Pilati","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Intraoperative Chemotherapy for Peritoneal Carcinomatosis Arising From Colon Adenocarcinoma","abstract":"<h4>Background</h4>Hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) has been recently proposed to treat peritoneal carcinomatosis arising from colon adenocarcinoma, which is usually regarded as a lethal clinical entity. The purpose of this study was to evaluate the clinical outcome of this combined treatment.<h4>Methods</h4>A retrospective study of 46 patients treated for peritoneal carcinomatosis from colon adenocarcinoma was performed. Thirty-four patients were treated with complete cytoreductive surgery immediately followed by intraoperative HIIC with mitomycin C and cisplatin. The clinical outcome of these 34 patients was analyzed; the median follow-up period was 14.5 months.<h4>Results</h4>No postoperative deaths were reported. The postoperative morbidity rate was 35%. No severe locoregional or systemic toxicity was observed. The 2-year overall survival was 31%, and the median survival time and the median time to local disease progression were 18 and 13 months, respectively. Survival and local disease control in patients with well- and moderately differentiated colon adenocarcinoma were significantly better than in those with poorly differentiated tumors.<h4>Conclusions</h4>Considering the dismal prognosis of this condition, HIIC seems to achieve encouraging results in a selected group of patients affected with resectable peritoneal carcinomatosis arising from colon adenocarcinoma. These findings support the conduction of formal phase III randomized trials.","is_dataset_classified":null,"base_score":4.859812404361672,"endowment":4.859812404361672,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12794016","pmcid":null,"openalex_id":"https://openalex.org/W1981762248","authors":[],"funders":[],"total_grants":0,"fwci":9.7762,"citation_percentile":0.98397127,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":7},{"year":2014,"count":8},{"year":2015,"count":2},{"year":2016,"count":9},{"year":2017,"count":3},{"year":2018,"count":5},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2024,"count":2}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://link.springer.com/content/pdf/10.1245/ASO.2003.08.004.pdf","host_type":"publisher"},{"url":"http://link.springer.com/article/10.1245/ASO.2003.08.004/fulltext.html","host_type":"publisher"},{"url":"http://link.springer.com/content/pdf/10.1245/ASO.2003.08.004","host_type":"publisher"},{"url":"https://doi.org/10.1245/aso.2003.08.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12794016","host_type":"repository"},{"url":"http://hdl.handle.net/11577/2455144","host_type":"repository"}],"fields_of_study":["Intraperitoneal and Appendiceal Malignancies","Occupational and environmental lung diseases","Intestinal and Peritoneal Adhesions","Adenocarcinoma","Adult","Aged","Antineoplastic Combined Chemotherapy Protocols","Carcinoma","Cell Differentiation","Cisplatin","Colonic Neoplasms","Combined Modality Therapy","Disease Progression","Female","Humans","Hyperthermia, Induced","Infusions, Parenteral","Male","Middle Aged","Mitomycin","Peritoneal Neoplasms","Prognosis","Survival Analysis","Treatment Outcome"],"mesh_terms":["Adenocarcinoma","Adult","Aged","Antineoplastic Combined Chemotherapy Protocols","Carcinoma","Cell Differentiation","Cisplatin","Colonic Neoplasms","Combined Modality Therapy","Female","Humans","Hyperthermia, Induced","Infusions, Parenteral","Male","Middle Aged","Peritoneal Neoplasms","Prognosis","Survival Analysis","Mitomycin","Treatment Outcome","Disease Progression"],"keywords":["Medicine","Hyperthermic intraperitoneal chemotherapy","Surgical oncology","Peritoneal carcinomatosis","Cytoreductive surgery","Intraperitoneal chemotherapy","Adenocarcinoma","General surgery","Chemotherapy","Oncology","Surgery","Colorectal cancer","Internal medicine","Cancer","Ovarian cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T14:35:04.825955Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}