{"doi":"10.1242/jeb.200.2.315","title":"Elementary and Global Aspects of Calcium Signalling","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Calcium is a ubiquitous second messenger used to regulate a wide range of cellular processes. This role in signalling has to be conducted against the rigid homeostatic mechanisms that ensure that the resting level of Ca2+ is kept low (i.e. between 20 and 100 nmol l−1) in order to avoid the cytotoxic effects of a prolonged elevation of [Ca2+]. Cells have evolved a sophisticated signalling system based on the generation of brief pulses of Ca2+ which enables this ion to be used as a messenger, thus avoiding its toxic effects. Such Ca2+ spikes usually result from the coordinated release of Ca2+ from internal stores using either inositol 1,4,5-trisphosphate or ryanodine receptors. Using Ca2+ imaging techniques, the opening of individual channels has now been visualized and models have been proposed to explain how these elementary events are coordinated to generate the global Ca2+ signals that regulate cellular activity.</jats:p>","journal":"Journal of Experimental Biology","year":1997,"id":26345,"datarank":9.575696300593266,"base_score":5.327876168789581,"endowment":5.327876168789581,"self_citation_contribution":0.7991814253184373,"citation_network_contribution":8.77651487527483,"self_endowment_contribution":0.7991814253184373,"citer_contribution":8.77651487527483,"corpus_percentile":null,"corpus_rank":null,"citation_count":205,"citer_count":200,"citers_with_citation_signal":177,"citers_with_endowment":177,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":152627,"name":"Michael J. Berridge","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.327876168789581,"endowment":5.327876168789581,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9050239","pmcid":null,"openalex_id":"https://openalex.org/W2240467006","authors":[],"funders":[],"total_grants":0,"fwci":4.049,"citation_percentile":0.94875256,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":9},{"year":2014,"count":9},{"year":2015,"count":7},{"year":2016,"count":2},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":6},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":5},{"year":2024,"count":6},{"year":2025,"count":6},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1/","oa_locations":[{"url":"https://journals.biologists.com/jeb/article-pdf/200/2/315/3403155/jexbio_200_2_315.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/jeb.200.2.315","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9050239","host_type":"repository"}],"fields_of_study":["Ion channel regulation and function","Neuroscience and Neuropharmacology Research","Calcium signaling and nucleotide metabolism","Animals","Calcium","Calcium Channels","Calcium Channels, L-Type","Cell Membrane","Homeostasis","Inositol 1,4,5-Trisphosphate","Intracellular Fluid","Models, Biological","Muscle Proteins","Organ Specificity","Periodicity","Ryanodine Receptor Calcium Release Channel","Second Messenger Systems"],"mesh_terms":["Animals","Calcium","Cell Membrane","Homeostasis","Intracellular Fluid","Models, Biological","Muscle Proteins","Organ Specificity","Periodicity","Calcium Channels","Second Messenger Systems","Inositol 1,4,5-Trisphosphate","Ryanodine Receptor Calcium Release Channel","Calcium Channels, L-Type"],"keywords":["Second messenger system","Signalling","Ryanodine receptor","Inositol","Calcium signaling","Calcium","Cell biology","Receptor","Homeostasis","Chemistry","Biophysics","Inositol trisphosphate","Inositol trisphosphate receptor","Biology","Neuroscience","Signal transduction","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T13:40:40.267440Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}