{"doi":"10.1242/jcs.113.11.1851","title":"The Shank family of scaffold proteins","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Shank proteins make up a new family of scaffold proteins recently identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank polypeptides contain multiple sites for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PDZ domain, a long proline-rich region, and a SAM domain. Binding partners for most of these domains have been identified: for instance, the PDZ domain of Shank proteins interacts with GKAP (a postsynaptic-density protein) as well as several G-protein-coupled receptors. The specific localization of Shank proteins at postsynaptic sites of brain excitatory synapses suggests a role for this family of proteins in the organization of cytoskeletal/ signaling complexes at specialized cell junctions.</jats:p>","journal":"Journal of Cell Science","year":2000,"id":24626,"datarank":13.875660343164835,"base_score":6.373319789577012,"endowment":6.373319789577012,"self_citation_contribution":0.9559979684365519,"citation_network_contribution":12.919662374728283,"self_endowment_contribution":0.9559979684365519,"citer_contribution":12.919662374728283,"corpus_percentile":null,"corpus_rank":null,"citation_count":585,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":24,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":147240,"name":"Eunjoon Kim","orcid":null,"position":1,"is_corresponding":false},{"id":147239,"name":"Morgan Sheng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.373319789577012,"endowment":6.373319789577012,"datacite_reuse_total":24,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10806096","pmcid":null,"openalex_id":"https://openalex.org/W1897589155","authors":[],"funders":[],"total_grants":0,"fwci":6.928,"citation_percentile":0.97339533,"influential_citations":0,"citation_trend":[{"year":2012,"count":29},{"year":2013,"count":25},{"year":2014,"count":22},{"year":2015,"count":35},{"year":2016,"count":31},{"year":2017,"count":25},{"year":2018,"count":24},{"year":2019,"count":17},{"year":2020,"count":32},{"year":2021,"count":26},{"year":2022,"count":23},{"year":2023,"count":26},{"year":2024,"count":25},{"year":2025,"count":25},{"year":2026,"count":6}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1/","oa_locations":[{"url":"https://journals.biologists.com/jcs/article-pdf/113/11/1851/3547659/joces_113_11_1851.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/jcs.113.11.1851","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10806096","host_type":"repository"},{"url":"http://hdl.handle.net/10203/3906","host_type":"repository"}],"fields_of_study":["Hippo pathway signaling and YAP/TAZ","Cellular transport and secretion","Protein Structure and Dynamics","Adaptor Proteins, Signal Transducing","Animals","Carrier Proteins","Nerve Tissue Proteins","Neurons","Nuclear Proteins"],"mesh_terms":["Animals","Carrier Proteins","Nerve Tissue Proteins","Neurons","Nuclear Proteins","Adaptor Proteins, Signal Transducing"],"keywords":["PDZ domain","Ankyrin repeat","Scaffold protein","Postsynaptic density","Biology","Cell biology","Cytoskeleton","Signal transducing adaptor protein","SH3 domain","Membrane protein","Ankyrin","Postsynaptic potential","Protein domain","Receptor","Signal transduction","Biochemistry","Cell","Membrane","Receptor tyrosine kinase","Gene"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.21268985.v1","title":"Additional file 1 of Enhanced fear limits behavioral flexibility in Shank2-deficient mice","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.21268985","title":"Additional file 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