{"doi":"10.1242/jcs.109.11.2609","title":"Protocadherins and diversity of the cadherin superfamily","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Recent cadherin studies have revealed that many cadherins and cadherin-related proteins are expressed in various tissues of different multicellular organisms. These proteins are characterized by the multiple repeats of the cadherin motif in their extracellular domains. The members of the cadherin superfamily are divided into two groups: classical cadherin type and protocadherin type. The current cadherins appear to have evolved from a protocadherin type. Recent studies have proved the cell adhesion role of classical cadherins in embryogenesis. In contrast, the bio-logical role of protocadherins is elusive. Circumstantial evidence, however, suggests that protocadherins are involved in a variety of cell-cell interactions. Since protocadherins, and many other new cadherins as well, have unique properties, studies of these cadherins may provide insight into the structure and biological role of the cadherin superfamily.</jats:p>","journal":"Journal of Cell Science","year":1996,"id":594244,"datarank":0.687745121800586,"base_score":4.584967478670572,"endowment":4.584967478670572,"self_citation_contribution":0.687745121800586,"citation_network_contribution":0.0,"self_endowment_contribution":0.687745121800586,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":97,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1521136,"name":"Shintaro T. Suzuki","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Protocadherins and diversity of the cadherin superfamily","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Recent cadherin studies have revealed that many cadherins and cadherin-related proteins are expressed in various tissues of different multicellular organisms. These proteins are characterized by the multiple repeats of the cadherin motif in their extracellular domains. The members of the cadherin superfamily are divided into two groups: classical cadherin type and protocadherin type. The current cadherins appear to have evolved from a protocadherin type. Recent studies have proved the cell adhesion role of classical cadherins in embryogenesis. In contrast, the bio-logical role of protocadherins is elusive. Circumstantial evidence, however, suggests that protocadherins are involved in a variety of cell-cell interactions. Since protocadherins, and many other new cadherins as well, have unique properties, studies of these cadherins may provide insight into the structure and biological role of the cadherin superfamily.</jats:p>","is_dataset_classified":null,"base_score":4.584967478670572,"endowment":4.584967478670572,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8937978","pmcid":null,"openalex_id":"https://openalex.org/W2341274362","authors":[],"funders":[],"total_grants":0,"fwci":1.7254,"citation_percentile":0.8524986,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":3},{"year":2014,"count":1},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":8}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1/","oa_locations":[{"url":"https://journals.biologists.com/jcs/article-pdf/109/11/2609/3332954/joces_109_11_2609.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/jcs.109.11.2609","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8937978","host_type":"repository"}],"fields_of_study":["Wnt/β-catenin signaling in development and cancer","Cancer-related gene regulation","Kruppel-like factors research","Animals","Cadherins"],"mesh_terms":["Animals","Cadherins"],"keywords":["Cadherin","Protocadherin","Biology","Multicellular organism","SUPERFAMILY","Cell adhesion","Cell biology","Cell","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.26656957.v1","title":"Additional file 3 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.26656957","title":"Additional file 3 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.26656951.v1","title":"Additional file 1 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26656951","title":"Additional file 1 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26656954.v1","title":"Additional file 2 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26656954","title":"Additional file 2 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26656963.v1","title":"Additional file 5 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26656963","title":"Additional file 5 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26656960.v1","title":"Additional file 4 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"Image"},{"doi":"10.6084/m9.figshare.26656960","title":"Additional file 4 of Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms","publisher":"figshare","resource_type":"Image"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T14:00:31.183719Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}