{"doi":"10.1242/dmm.049810","title":"A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models","abstract":"Although renal macrophages have been shown to contribute to cyst development in polycystic kidney disease (PKD) animal models, it remains unclear whether there is a specific macrophage subpopulation involved. Here, we analyzed changes in macrophage populations during renal maturation in association with cystogenesis rates in conditional Pkd2 mutant mice. We observed that CD206+ resident macrophages were minimal in a normal adult kidney but accumulated in cystic areas in adult-induced Pkd2 mutants. Using Cx3cr1 null mice, we reduced macrophage number, including CD206+ macrophages, and showed that this significantly reduced cyst severity in adult-induced Pkd2 mutant kidneys. We also found that the number of CD206+ resident macrophage-like cells increased in kidneys and in the urine from autosomal-dominant PKD (ADPKD) patients relative to the rate of renal functional decline. These data indicate a direct correlation between CD206+ resident macrophages and cyst formation, and reveal that the CD206+ resident macrophages in urine could serve as a biomarker for renal cystic disease activity in preclinical models and ADPKD patients. This article has an associated First Person interview with the first author of the paper.","journal":"Disease Models & Mechanisms","year":2022,"id":260459,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":15661,"name":"Kurt A. Zimmerman","orcid":"0000-0003-1798-8046","position":1,"is_corresponding":false},{"id":914160,"name":"Sreelakshmi Cherakara","orcid":"0000-0003-2617-3236","position":2,"is_corresponding":false},{"id":914696,"name":"Phillip Chumley","orcid":null,"position":3,"is_corresponding":false},{"id":259914,"name":"James F. Collawn","orcid":"0000-0002-2528-2759","position":4,"is_corresponding":false},{"id":568648,"name":"Jun Wang","orcid":"0000-0002-3413-5208","position":5,"is_corresponding":false},{"id":583999,"name":"Courtney J. Haycraft","orcid":null,"position":6,"is_corresponding":false},{"id":779514,"name":"Cheng Song","orcid":"0000-0001-9541-8909","position":7,"is_corresponding":false},{"id":914697,"name":"Teresa Chacana","orcid":null,"position":8,"is_corresponding":false},{"id":583548,"name":"Reagan S. Andersen","orcid":"0000-0003-0840-1952","position":9,"is_corresponding":false},{"id":583549,"name":"Mandy J. Croyle","orcid":"0000-0001-5208-0530","position":10,"is_corresponding":false},{"id":779933,"name":"Ernald J. Aloria","orcid":null,"position":11,"is_corresponding":false},{"id":914698,"name":"Raksha P. Hombal","orcid":null,"position":12,"is_corresponding":false},{"id":914699,"name":"Isis Thomas","orcid":null,"position":13,"is_corresponding":false},{"id":416462,"name":"Hanan Chweih","orcid":"0000-0002-6358-3579","position":14,"is_corresponding":false},{"id":914700,"name":"Kristin L. Simanyi","orcid":null,"position":15,"is_corresponding":false},{"id":854371,"name":"James F. George","orcid":"0000-0003-0325-7891","position":16,"is_corresponding":false},{"id":371212,"name":"John M. Parant","orcid":"0000-0001-9084-5098","position":17,"is_corresponding":false},{"id":305251,"name":"Michal Mrug","orcid":"0000-0001-8981-1843","position":18,"is_corresponding":false},{"id":371213,"name":"Bradley K. Yoder","orcid":"0000-0002-0247-1944","position":19,"is_corresponding":false},{"id":639002,"name":"Zhang Li","orcid":"0000-0002-3796-0369","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T00:26:07.666421Z","pmid":"36457161","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}