{"doi":"10.1242/dev.204373","title":"<i>miR-137</i> targets <i>Myc</i> to regulate growth during eye development","abstract":"During development, regulation of gene expression is key to cellular homeostasis. Gene expression regulation by non-coding RNAs involves the prevention of mRNA accumulation or the inhibition of translation of their target gene. In a forward-genetic screen to identify the microRNA involved in the growth and patterning of the Drosophila eye, we identified the highly conserved miR-137. Gain of function of miR-137 results in a reduced-eye phenotype by downregulating retinal determination and differentiation markers, and by upregulating negative regulators of eye development, such as Wingless (Wg) and Homothorax (Hth). Loss of function of miR-137 results in an enlarged-eye phenotype. Using bioinformatics and genetic approaches, we identified the oncogene Myc as the target of miR-137. Gain of function of Myc can rescue the reduced-eye phenotype of miR-137 gain of function, and vice versa. We tested the role of miR-137 in regulating Myc levels in the RasV12;scribRNAi, a tumor model of oncogenic cooperation that results in neoplastic tumors. Gain of function of miR-137 in the RasV12;scribRNAi background significantly reduced tumor phenotype as well as Myc levels in the eye. Our studies highlight miR-137 as a post-transcriptional regulator of Myc and a promising therapeutic target for diseases associated with Myc accumulation.","journal":"Development","year":2025,"id":526064,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1401133,"name":"Manivannan Subramanian","orcid":"0000-0002-3341-3739","position":1,"is_corresponding":false},{"id":445752,"name":"Anuradha Venkatakrishnan Chimata","orcid":"0000-0002-8499-7404","position":2,"is_corresponding":false},{"id":1344061,"name":"Arushi Rai","orcid":null,"position":3,"is_corresponding":false},{"id":1401562,"name":"Sunanda Yogi","orcid":null,"position":4,"is_corresponding":false},{"id":1119681,"name":"Anjali Sangeeth","orcid":"0000-0003-1106-5013","position":5,"is_corresponding":false},{"id":450825,"name":"Madhuri Kango‐Singh","orcid":"0000-0003-2447-6997","position":6,"is_corresponding":false},{"id":445753,"name":"Amit Singh","orcid":"0000-0002-2962-2255","position":7,"is_corresponding":false},{"id":1401132,"name":"Radhika Padma","orcid":"0000-0002-5064-0706","position":0,"is_corresponding":true}],"reference_count":128,"raw_metadata":null,"created_at":"2026-07-19T02:50:25.860105Z","pmid":"40554764","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}