{"doi":"10.1242/dev.201974","title":"GRD-1/PTR-11, the <i>C. elegans</i> hedgehog/patched-like morphogen-receptor pair, modulates developmental rate","abstract":"Both hedgehog (Hh) and target of rapamycin complex 2 (TORC2) are central, evolutionarily conserved signaling pathways that regulate development and metabolism. In C. elegans, loss of the essential TORC2 component RICTOR (rict-1) causes delayed development, shortened lifespan, reduced brood, small size and increased fat. Here, we report that knockdown of both the hedgehog-related morphogen grd-1 and its patched-related receptor ptr-11 rescues delayed development in TORC2 loss-of-function mutants, and grd-1 and ptr-11 overexpression delays wild-type development to a similar level to that in TORC2 loss-of-function animals. These findings potentially indicate an unexpected role for grd-1 and ptr-11 in slowing developmental rate downstream of a nutrient-sensing pathway. Furthermore, we implicate the chronic stress transcription factor pqm-1 as a key transcriptional effector in this slowing of whole-organism growth by grd-1 and ptr-11. We propose that TORC2, grd-1 and ptr-11 may act linearly or converge on pqm-1 to delay organismal development.","journal":"Development","year":2023,"id":369675,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":920523,"name":"Armen Yerevanian","orcid":"0000-0003-4985-1028","position":1,"is_corresponding":false},{"id":329573,"name":"Fasih M. Ahsan","orcid":"0000-0001-8031-7056","position":2,"is_corresponding":false},{"id":1128611,"name":"Jen F. Rotti","orcid":"0009-0002-8044-2134","position":3,"is_corresponding":false},{"id":920526,"name":"Yifei Zhou","orcid":"0000-0003-0088-6262","position":4,"is_corresponding":false},{"id":921143,"name":"Lucydalila Cedillo","orcid":null,"position":5,"is_corresponding":false},{"id":299215,"name":"Alexander A. Soukas","orcid":"0000-0002-9100-2436","position":6,"is_corresponding":false},{"id":920525,"name":"Sinclair Emans","orcid":"0009-0005-3285-2472","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T01:15:32.670954Z","pmid":"37982457","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}