{"doi":"10.1242/dev.201266","title":"Melanocyte lineage dynamics in development, growth and disease","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Melanocytes evolved to produce the melanin that gives colour to our hair, eyes and skin. The melanocyte lineage also gives rise to melanoma, the most lethal form of skin cancer. The melanocyte lineage differentiates from neural crest cells during development, and most melanocytes reside in the skin and hair, where they are replenished by melanocyte stem cells. Because the molecular mechanisms necessary for melanocyte specification, migration, proliferation and differentiation are co-opted during melanoma initiation and progression, studying melanocyte development is directly relevant to human disease. Here, through the lens of advances in cellular omic and genomic technologies, we review the latest findings in melanocyte development and differentiation, and how these developmental pathways become dysregulated in disease.</jats:p>","journal":"Development","year":2024,"id":650008,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356749,"name":"E. Elizabeth Patton","orcid":"0000-0002-2570-0834","position":1,"is_corresponding":false},{"id":356740,"name":"Alessandro Brombin","orcid":"0000-0001-8262-9248","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Melanocyte lineage dynamics in development, growth and disease","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Melanocytes evolved to produce the melanin that gives colour to our hair, eyes and skin. The melanocyte lineage also gives rise to melanoma, the most lethal form of skin cancer. The melanocyte lineage differentiates from neural crest cells during development, and most melanocytes reside in the skin and hair, where they are replenished by melanocyte stem cells. Because the molecular mechanisms necessary for melanocyte specification, migration, proliferation and differentiation are co-opted during melanoma initiation and progression, studying melanocyte development is directly relevant to human disease. Here, through the lens of advances in cellular omic and genomic technologies, we review the latest findings in melanocyte development and differentiation, and how these developmental pathways become dysregulated in disease.</jats:p>","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39092608","pmcid":"PMC11317096","openalex_id":"https://openalex.org/W4401269943","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MC_UU_00035/13","title":"Targeting developmental cell states in melanoma"},{"funder_name":"Rosetrees Trust","grant_id":"687306","title":null},{"funder_name":"Rosetrees Trust","grant_id":"917226","title":null},{"funder_name":"Cancer Research UK","grant_id":"CTRQQR-2021\\100006","title":null},{"funder_name":"University of Edinburgh","grant_id":"","title":null},{"funder_name":"Melanoma Research Alliance","grant_id":"","title":null},{"funder_name":"Melanoma Research Alliance","grant_id":"","title":null},{"funder_name":"University of Edinburgh","grant_id":"","title":null}],"total_grants":8,"fwci":7.886,"citation_percentile":0.98513108,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":18},{"year":2026,"count":13}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://journals.biologists.com/dev/article-pdf/151/15/dev201266/3556975/dev201266.pdf","host_type":"journal"},{"url":"https://journals.biologists.com/dev/article-pdf/151/15/dev201266/3556975/dev201266.pdf","host_type":"publisher"},{"url":"https://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.201266/3556975/dev201266.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.201266","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39092608","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11317096","host_type":"repository"},{"url":"https://www.research.ed.ac.uk/en/publications/92d2c741-5c47-4bbc-bb4c-73fb0e37f0b1","host_type":"repository"},{"url":"https://www.research.ed.ac.uk/files/448422531/Brombin_Patton_Review_Development.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11317096","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1242/dev.201266","host_type":""}],"fields_of_study":["melanin and skin pigmentation","Immunotherapy and Immune Responses","RNA regulation and disease","0301 basic medicine","0303 health sciences","03 medical and health sciences","Melanocytes","Humans","Cell Lineage","Cell Differentiation","Animals","Melanoma","Neural Crest","Cell Proliferation","Skin Neoplasms"],"mesh_terms":["Animals","Cell Differentiation","Humans","Melanocytes","Melanoma","Neural Crest","Skin Neoplasms","Cell Lineage","Cell Proliferation"],"keywords":["Melanocyte","Biology","Neural crest","Melanin","Lineage (genetic)","Microphthalmia-associated transcription factor","Melanoma","Cell biology","Cancer research","Genetics","Gene","Transcription factor","Embryo","Genomics","Melanocytes","Pigmentation","Transcriptomics","Mitf","Multi-omics","Melanocyte Stem Cells","Schwann Cell Precursor","Pigmentary Disease","Scrna-sequencing","Skin Neoplasms","Humans","Animals","Cell Lineage","Cell Differentiation","Review","Cell Proliferation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:41:20.916609Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}