{"doi":"10.1242/dev.199493","title":"Lineage-specific control of convergent differentiation by a Forkhead repressor","abstract":"During convergent differentiation, multiple developmental lineages produce a highly similar or identical cell type. However, few molecular players that drive convergent differentiation are known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification of cells related by lineage rather than by cell type or function. Specification defects correlate with UNC-130:DNA binding, and UNC-130 can be functionally replaced by its human homolog, the neural crest lineage determinant FoxD3. We propose that, in contrast to terminal selectors that activate cell type-specific transcriptional programs in terminally differentiating cells, UNC-130 acts early and specifically in one convergent lineage to produce a cell type that also arises from molecularly distinct progenitors in other lineages.","journal":"Development","year":2021,"id":180561,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9498,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":23562,"name":"Julia M. Rogers","orcid":"0000-0001-6518-5470","position":1,"is_corresponding":false},{"id":729868,"name":"Jonathan D. Rumley","orcid":"0000-0002-5962-7575","position":2,"is_corresponding":false},{"id":233475,"name":"Shai Shaham","orcid":"0000-0002-3751-975X","position":3,"is_corresponding":false},{"id":557014,"name":"Martha L. Bulyk","orcid":"0000-0002-3456-4555","position":4,"is_corresponding":false},{"id":53163,"name":"John I. Murray","orcid":"0000-0003-4026-584X","position":5,"is_corresponding":false},{"id":443791,"name":"Maxwell G. Heiman","orcid":"0000-0002-2557-6490","position":6,"is_corresponding":false},{"id":729867,"name":"Karolina Mizeracka","orcid":"0000-0002-2472-2310","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-18T23:47:57.268805Z","pmid":"34423346","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}