{"doi":"10.1242/dev.197319","title":"A lineage-specific requirement for YY1 Polycomb Group protein function in early T cell development","abstract":"Yin Yang 1 (YY1) is a ubiquitous transcription factor and mammalian Polycomb Group protein (PcG) with important functions for regulating lymphocyte development and stem cell self-renewal. YY1 mediates stable PcG-dependent transcriptional repression via recruitment of PcG proteins that result in histone modifications. Many questions remain unanswered regarding how cell- and tissue-specificity is achieved by PcG proteins. Here, we demonstrate that a conditional knockout of Yy1 in the hematopoietic system results in an early T cell developmental blockage at the double negative (DN) 1 stage with reduced Notch1 signaling. There is a lineage-specific requirement for YY1 PcG function. YY1 PcG domain is required for T and B cell development but not necessary for myeloid cells. YY1 functions in early T cell development are multicomponent and involve both PcG-dependent and -independent regulations. Although YY1 promotes early T cell survival through its PcG function, its function to promote the DN1-to-DN2 transition and Notch1 expression and signaling is independent of its PcG function. Our results reveal how a ubiquitously expressed PcG protein mediates lineage-specific and context-specific functions to control early T cell development.","journal":"Development","year":2021,"id":181071,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":731912,"name":"Guoping Fu","orcid":null,"position":1,"is_corresponding":false},{"id":731294,"name":"Deependra Kumar Singh","orcid":"0000-0002-4141-7668","position":2,"is_corresponding":false},{"id":731295,"name":"Zhanping Lu","orcid":"0000-0002-0586-9050","position":3,"is_corresponding":false},{"id":731913,"name":"Ashley M. Kuehnl","orcid":null,"position":4,"is_corresponding":false},{"id":43201,"name":"Rene Welch","orcid":"0000-0001-9861-530X","position":5,"is_corresponding":false},{"id":298238,"name":"Irene M. Ong","orcid":"0000-0002-9353-6941","position":6,"is_corresponding":false},{"id":731296,"name":"Renren Wen","orcid":"0000-0003-2420-8212","position":7,"is_corresponding":false},{"id":465405,"name":"Xuan Pan","orcid":"0000-0002-8308-8495","position":8,"is_corresponding":false},{"id":731911,"name":"Anna Luiza Facchetti Vinhaes Assumpção","orcid":null,"position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T23:48:01.257885Z","pmid":"33766932","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}