{"doi":"10.1242/dev.193995","title":"BLMP-1 promotes developmental cell death in <i>C. elegans</i> by timely repression of <i>ced-9</i> transcription","abstract":"Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally regulated is less understood. Here, we report a mechanism controlling tail-spike cell death onset during Caenorhabditis elegans development. We show that the zinc-finger transcription factor BLMP-1, which controls larval development timing, also regulates embryonic tail-spike cell death initiation. BLMP-1 functions upstream of CED-9 and in parallel to DRE-1, another CED-9 and tail-spike cell death regulator. BLMP-1 expression is detected in the tail-spike cell shortly after the cell is born, and blmp-1 mutations promote ced-9-dependent tail-spike cell survival. BLMP-1 binds ced-9 gene regulatory sequences, and inhibits ced-9 transcription just before cell-death onset. BLMP-1 and DRE-1 function together to regulate developmental timing, and their mammalian homologs regulate B-lymphocyte fate. Our results, therefore, identify roles for developmental timing genes in cell-death initiation, and suggest conservation of these functions.","journal":"Development","year":2021,"id":184588,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":464296,"name":"Piya Ghose","orcid":"0000-0001-5612-617X","position":1,"is_corresponding":false},{"id":739868,"name":"Hsiao‐Fen Han","orcid":"0000-0003-4207-8722","position":2,"is_corresponding":false},{"id":739869,"name":"Yunzhe Wu","orcid":"0000-0001-7143-0620","position":3,"is_corresponding":false},{"id":739870,"name":"Ya-Yin Tsai","orcid":"0000-0002-9152-7646","position":4,"is_corresponding":false},{"id":740495,"name":"Huang‐Chin Lin","orcid":null,"position":5,"is_corresponding":false},{"id":739871,"name":"Wei‐Chin Tseng","orcid":"0000-0001-5677-6527","position":6,"is_corresponding":false},{"id":494479,"name":"Jui-Ching Wu","orcid":"0000-0002-3880-9652","position":7,"is_corresponding":false},{"id":233475,"name":"Shai Shaham","orcid":"0000-0002-3751-975X","position":8,"is_corresponding":false},{"id":50274,"name":"Yi‐Chun Wu","orcid":"0000-0002-8621-4098","position":9,"is_corresponding":false},{"id":739867,"name":"Hang-Shiang Jiang","orcid":"0000-0002-3366-8600","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T23:48:30.970730Z","pmid":"34541605","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}