{"doi":"10.1242/dev.186395","title":"Circulating Hedgehog: a fresh view of a classic morphogen","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Members of the Hedgehog family of morphogens mediate the intercellular communication necessary for the organisation and development of many animal tissues. They are modified by various lipid adducts, rendering them insoluble in hydrophilic environments and leading to the contentious question of how these molecules travel in the aqueous extracellular space. Seminal work carried out by Suzanne Eaton and her colleagues has shed light on how these morphogens can spread over long distances through their association with lipoprotein particles. In this Spotlight article, we discuss Suzanne's pioneering work and her contribution to our understanding of the transport and activity of morphogens, in particular Hedgehog. We also describe two other essential aspects of her work: the discovery and characterisation of endogenously present Hedgehog variants, as well as her proposition that, in addition to its role as a morphogen, Hedgehog acts as an endocrine hormone.</jats:p>","journal":"Development","year":2020,"id":622123,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1410513,"name":"Julien Marcetteau","orcid":null,"position":1,"is_corresponding":false},{"id":385004,"name":"Pascal P. Thérond","orcid":"0000-0003-0434-2334","position":2,"is_corresponding":false},{"id":1196886,"name":"Elodie Prince","orcid":"0000-0001-7361-1396","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Circulating Hedgehog: a fresh view of a classic morphogen","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Members of the Hedgehog family of morphogens mediate the intercellular communication necessary for the organisation and development of many animal tissues. They are modified by various lipid adducts, rendering them insoluble in hydrophilic environments and leading to the contentious question of how these molecules travel in the aqueous extracellular space. Seminal work carried out by Suzanne Eaton and her colleagues has shed light on how these morphogens can spread over long distances through their association with lipoprotein particles. In this Spotlight article, we discuss Suzanne's pioneering work and her contribution to our understanding of the transport and activity of morphogens, in particular Hedgehog. We also describe two other essential aspects of her work: the discovery and characterisation of endogenously present Hedgehog variants, as well as her proposition that, in addition to its role as a morphogen, Hedgehog acts as an endocrine hormone.</jats:p>","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33355241","pmcid":null,"openalex_id":"https://openalex.org/W3115585887","authors":[],"funders":[{"funder_name":"Agence Nationale de la Recherche","grant_id":"ANR-18-CE13-0003","title":"Identification of a new protein signature of extracellular vesicles involved in embryonic development and pathology"},{"funder_name":"LABEX","grant_id":"ANR-11-LABX-0028-01","title":null},{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-11-LABX-0028","title":null}],"total_grants":3,"fwci":0.3728,"citation_percentile":0.56882241,"influential_citations":0,"citation_trend":[{"year":2020,"count":3},{"year":2021,"count":1},{"year":2023,"count":1},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://www.biologists.com/user-licence-1-1","oa_locations":[{"url":"https://journals.biologists.com/dev/article-pdf/147/24/dev186395/1969908/dev186395.pdf","host_type":"journal"},{"url":"https://journals.biologists.com/dev/article-pdf/147/24/dev186395/1969908/dev186395.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1242/dev.186395","host_type":"publisher"},{"url":"http://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.186395/1969908/dev186395.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.186395","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33355241","host_type":"repository"},{"url":"https://hal.science/hal-03431549","host_type":"repository"},{"url":"https://hal.science/hal-03432446","host_type":"repository"},{"url":"http://dev.biologists.org/cgi/content/short/147/24/dev186395","host_type":"repository"},{"url":"https://hal.science/hal-03432446v1","host_type":""},{"url":"https://hal.science/hal-03432446v1/document","host_type":""},{"url":"https://dx.doi.org/10.1242/dev.186395","host_type":""}],"fields_of_study":["Hedgehog Signaling Pathway Studies","dental development and anomalies","Oral and Maxillofacial Pathology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Cell Communication","Drosophila Proteins","Hedgehog Proteins","Hydrophobic and Hydrophilic Interactions","Morphogenesis","Signal Transduction","Wings, Animal","Wnt Proteins"],"mesh_terms":["Animals","Cell Communication","Morphogenesis","Wings, Animal","Signal Transduction","Drosophila Proteins","Wnt Proteins","Hedgehog Proteins","Hydrophobic and Hydrophilic Interactions"],"keywords":["Morphogen","Hedgehog","Biology","Hedgehog signaling pathway","Evolutionary biology","Cell biology","Genetics","Signal transduction","Gene","Lipoproteins","Signalling","Endocannabinoids","Morphogens","Endocrine Hormone","Hedgehog/wingless","Cell Communication","[SDV] Life Sciences [q-bio]","Wnt Proteins","Morphogenesis","Animals","Drosophila Proteins","Wings, Animal","Hedgehog Proteins","Hydrophobic and Hydrophilic Interactions"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T18:18:10.659586Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}