{"doi":"10.1242/dev.181099","title":"Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in <i>C. elegans</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>Although cytokinesis has been intensely studied, the way it is executed during development is not well understood, despite a long-standing appreciation that various aspects of cytokinesis vary across cell and tissue types. To address this, we investigated cytokinesis during the invariant Caenorhabditis elegans embryonic divisions and found several parameters that are altered at different stages in a reproducible manner. During early divisions, furrow ingression asymmetry and midbody inheritance is consistent, suggesting specific regulation of these events. During morphogenesis, we found several unexpected alterations to cytokinesis, including apical midbody migration in polarizing epithelial cells of the gut, pharynx and sensory neurons. Aurora B kinase, which is essential for several aspects of cytokinesis, remains apically localized in each of these tissues after internalization of midbody ring components. Aurora B inactivation disrupts cytokinesis and causes defects in apical structures, even if inactivated post-mitotically. Therefore, we demonstrate that cytokinesis is implemented in a specialized way during epithelial polarization and that Aurora B has a role in the formation of the apical surface.</jats:p>","journal":"Development","year":2020,"id":42637,"datarank":0.98124172754039,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.46614364686761806,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.46614364686761806,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":29,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":203822,"name":"Michael Melesse","orcid":null,"position":1,"is_corresponding":false},{"id":203824,"name":"Christopher G. Sorensen Turpin","orcid":null,"position":2,"is_corresponding":false},{"id":203826,"name":"Dillon E. Sloan","orcid":"0000-0001-6065-176X","position":3,"is_corresponding":false},{"id":203828,"name":"Chin-Yi Chen","orcid":null,"position":4,"is_corresponding":false},{"id":203830,"name":"Wen-Cheng Wang","orcid":null,"position":5,"is_corresponding":false},{"id":203832,"name":"Po-Yi Lee","orcid":null,"position":6,"is_corresponding":false},{"id":203834,"name":"James R. Simmons","orcid":null,"position":7,"is_corresponding":false},{"id":203835,"name":"Benjamin Nebenfuehr","orcid":null,"position":8,"is_corresponding":false},{"id":203836,"name":"Diana Mitchell","orcid":"0000-0003-3788-2265","position":9,"is_corresponding":false},{"id":203837,"name":"Lindsey R. Klebanow","orcid":"0000-0002-0125-2619","position":10,"is_corresponding":false},{"id":203838,"name":"Nicholas Mattson","orcid":"0000-0002-6950-9222","position":11,"is_corresponding":false},{"id":62796,"name":"Eric Betzig","orcid":"0000-0002-4192-1274","position":12,"is_corresponding":false},{"id":151230,"name":"Bi-Chang Chen","orcid":"0000-0002-1876-7432","position":13,"is_corresponding":false},{"id":203839,"name":"Dhanya Cheerambathur","orcid":null,"position":14,"is_corresponding":false},{"id":203840,"name":"Joshua N. Bembenek","orcid":"0000-0002-0966-2268","position":15,"is_corresponding":false},{"id":203820,"name":"Xiaofei Bai","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31806662","pmcid":"PMC6983721","openalex_id":"https://openalex.org/W2992925002","authors":[],"funders":[{"funder_name":"Ministry of Science and Technology, Taiwan","grant_id":"105-2119-M-001-026-MY2","title":null},{"funder_name":"Wellcome Trust","grant_id":"203149, 208833","title":null},{"funder_name":"National Institutes of Health","grant_id":"R01 GM114471","title":null},{"funder_name":"NIH HHS","grant_id":"P40 OD010440","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"U41 HG002223","title":null},{"funder_name":"Wellcome Trust","grant_id":"208833/Z/17/Z","title":null},{"funder_name":"Wellcome Trust","grant_id":"203149","title":null},{"funder_name":"Wellcome Trust","grant_id":"208833","title":"Molecular mechanisms driving the formation of the neuronal microtubule cytoskeleton"},{"funder_name":"National Institutes of Health","grant_id":"1P40OD010440-01","title":"Caenorhabditis Genetics Center"},{"funder_name":"National Institutes of Health","grant_id":"3U41HG002223-17S1","title":"WormBase:  a core data resource for C. elegans and other nematodes"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM114471-05","title":"Cell Cycle Regulation of Membrane Trafficking"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":12,"fwci":1.1968,"citation_percentile":0.79326039,"influential_citations":1,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":7},{"year":2022,"count":3},{"year":2023,"count":9},{"year":2024,"count":4},{"year":2025,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://dev.biologists.org/content/develop/147/1/dev181099.full.pdf","host_type":"journal"},{"url":"https://dev.biologists.org/content/develop/147/1/dev181099.full.pdf","host_type":"HYBRID"},{"url":"https://dev.biologists.org/content/develop/147/1/dev181099.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1242/dev.181099","host_type":"publisher"},{"url":"https://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.181099/3480989/dev181099.pdf","host_type":"publisher"},{"url":"http://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.181099/2064287/dev_181099v1.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.181099","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31806662","host_type":"repository"},{"url":"https://www.research.ed.ac.uk/en/publications/0487d1ea-e4fd-42a9-8a95-905c193c5a48","host_type":"repository"},{"url":"https://www.osti.gov/biblio/1669750","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6983721","host_type":"repository"},{"url":"https://hdl.handle.net/20.500.11820/0487d1ea-e4fd-42a9-8a95-905c193c5a48","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6983721","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1242/dev.181099","host_type":""},{"url":"https://dx.doi.org/10.1242/dev.181099","host_type":""},{"url":"https://www.pure.ed.ac.uk/ws/files/132215905/dev181099.full.pdf","host_type":""}],"fields_of_study":["Photosynthetic Processes and Mechanisms","Genetics, Aging, and Longevity in Model Organisms","Microtubule and mitosis dynamics","Biology","Medicine","0301 basic medicine","03 medical and health sciences"],"mesh_terms":["Animals","Dendrites","Embryo, Nonmammalian","Epithelial Cells","Intestines","Morphogenesis","Neurons","Pharynx","Surface Properties","Cell Polarity","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Cytokinesis","Aurora Kinase B"],"keywords":["Cytokinesis","Midbody","Biology","Cell biology","Aurora B kinase","Septin","Ingression","Morphogenesis","Cell division","Cell","Genetics","Apical Surface","Neurons","Embryo, Nonmammalian","Surface Properties","Cell Polarity","Epithelial Cells","Dendrites","Intestines","Animals","Aurora Kinase B","Pharynx","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Research Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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