{"doi":"10.1242/dev.156059","title":"Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young neurons for the olfactory bulb (OB) and hippocampus, respectively, are generated. Recent studies have significantly modified earlier views on the mechanisms of NSC self-renewal and neurogenesis in the adult brain. Here, we discuss the molecular control, heterogeneity, regional specification and cell division modes of V-SVZ NSCs, and draw comparisons with NSCs in the SGZ. We highlight how V-SVZ NSCs are regulated by local signals from their immediate neighbors, as well as by neurotransmitters and factors that are secreted by distant neurons, the choroid plexus and vasculature. We also review recent advances in single cell RNA analyses that reveal the complexity of adult neurogenesis. These findings set the stage for a better understanding of adult neurogenesis, a process that one day may inspire new approaches to brain repair.</jats:p>","journal":"Development","year":2019,"id":41805,"datarank":6.934141408342579,"base_score":6.3835066348840055,"endowment":6.3835066348840055,"self_citation_contribution":0.957525995232601,"citation_network_contribution":5.976615413109978,"self_endowment_contribution":0.957525995232601,"citer_contribution":5.976615413109978,"corpus_percentile":null,"corpus_rank":null,"citation_count":591,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":200918,"name":"Arturo Alvarez-Buylla","orcid":"0000-0003-4426-8925","position":1,"is_corresponding":false},{"id":1469,"name":"Kirsten Obernier","orcid":"0000-0002-4025-1299","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.3835066348840055,"endowment":6.3835066348840055,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30777863","pmcid":"PMC6398449","openalex_id":"https://openalex.org/W2915097886","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"NS28478","title":null},{"funder_name":"National Institutes of Health","grant_id":"HD32116","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R37 HD032116","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R37 NS028478","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS028478","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD032116","title":null}],"total_grants":6,"fwci":34.2035,"citation_percentile":0.99876238,"influential_citations":21,"citation_trend":[{"year":2019,"count":29},{"year":2020,"count":67},{"year":2021,"count":94},{"year":2022,"count":99},{"year":2023,"count":93},{"year":2024,"count":87},{"year":2025,"count":90},{"year":2026,"count":32}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1","oa_locations":[{"url":"https://dev.biologists.org/content/develop/146/4/dev156059.full.pdf","host_type":"GREEN"},{"url":"https://syndication.highwire.org/content/doi/10.1242/dev.156059","host_type":"publisher"},{"url":"https://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.156059/3478965/dev156059.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.156059","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30777863","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398449","host_type":"repository"},{"url":"http://dev.biologists.org/cgi/content/short/146/4/dev156059","host_type":"repository"}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Neuroinflammation and Neurodegeneration Mechanisms","MicroRNA in disease regulation","Medicine","Biology","Adult Stem Cells","Animals","Cell Communication","Cell Differentiation","Cell Lineage","Embryonic Stem Cells","Hippocampus","Humans","Interneurons","Lateral Ventricles","Mice","Neural Stem Cells","Neurogenesis","Neurons","Olfactory Bulb","Sequence Analysis, RNA","Signal Transduction","Single-Cell Analysis","Transcriptome"],"mesh_terms":["Animals","Cell Communication","Cell Differentiation","Hippocampus","Humans","Interneurons","Neurons","Olfactory Bulb","Signal Transduction","Sequence Analysis, RNA","Cell Lineage","Lateral Ventricles","Mice","Embryonic Stem Cells","Adult Stem Cells","Neurogenesis","Neural Stem Cells","Single-Cell Analysis","Transcriptome"],"keywords":["Neurogenesis","Subventricular zone","Subgranular zone","Biology","Neural stem cell","Neuroscience","Olfactory bulb","Choroid plexus","Mammalian brain","Hippocampus","Stem cell","Cell biology","Central nervous system","Differentiation","Neural stem cells","self-renewal","Transcriptomics","Stem Cell Heterogeneity"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.19185785.v1","title":"Additional file 1 of Change of hypothalamic adult neurogenesis in mice by chronic treatment of fluoxetine","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19185785","title":"Additional file 1 of Change of hypothalamic adult neurogenesis in mice by chronic treatment of fluoxetine","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19185788.v1","title":"Additional file 2 of Change of hypothalamic adult neurogenesis in mice by chronic treatment of fluoxetine","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19185788","title":"Additional file 2 of Change of hypothalamic adult neurogenesis in mice by chronic treatment of 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