{"doi":"10.1242/dev.127.9.1911","title":"The conditional medaka mutation <i>eyeless</i> uncouples patterning and morphogenesis of the eye","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>In early vertebrate eye development, the retinal anlage is specified in the anterior neuroectoderm. During neurulation, the optic vesicles evaginate from the lateral wall of the prosencephalon. Here we describe the temperature-sensitive mutation eyeless in the Japanese medakafish. Marker gene analysis indicates that, whereas, specification of two retinal primordia and proximodistal patterning takes place in the mutant embryo, optic vesicle evagination does not occur and subsequent differentiation of the retinal primordia is not observed. The mutation eyeless thus uncouples patterning and morphogenesis at early steps of retinal development. Temperature-shift experiments indicate a requirement for eyeless activity prior to optic vesicle evagination. Cell transplantation shows that eyeless acts cell autonomously.</jats:p>","journal":"Development","year":2000,"id":23088,"datarank":3.5673543511860144,"base_score":4.574710978503383,"endowment":4.574710978503383,"self_citation_contribution":0.6862066467755076,"citation_network_contribution":2.8811477044105067,"self_endowment_contribution":0.6862066467755076,"citer_contribution":2.8811477044105067,"corpus_percentile":null,"corpus_rank":null,"citation_count":96,"citer_count":74,"citers_with_citation_signal":67,"citers_with_endowment":67,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":142992,"name":"Felix Loosli","orcid":null,"position":1,"is_corresponding":false},{"id":91909,"name":"Thorsten Henrich","orcid":null,"position":2,"is_corresponding":false},{"id":142993,"name":"Yuko Wakamatsu","orcid":null,"position":3,"is_corresponding":false},{"id":142994,"name":"Joachim Wittbrodt","orcid":null,"position":4,"is_corresponding":false},{"id":74514,"name":"Sylke Winkler","orcid":"0000-0002-0915-3316","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.574710978503383,"endowment":4.574710978503383,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10751179","pmcid":null,"openalex_id":"https://openalex.org/W2186359719","authors":[],"funders":[],"total_grants":0,"fwci":2.576,"citation_percentile":0.89986151,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":3},{"year":2021,"count":5},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1/","oa_locations":[{"url":"https://journals.biologists.com/dev/article-pdf/127/9/1911/2845594/develop_127_9_1911.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.127.9.1911","host_type":"journal"}],"fields_of_study":["Developmental Biology and Gene Regulation","Retinal Development and Disorders","Zebrafish Biomedical Research Applications","Animals","Apoptosis","Body Patterning","Brain","Cell Division","DNA-Binding Proteins","Drosophila Proteins","Eye","Eye Proteins","Gene Expression Regulation, Developmental","Genes, Recessive","Homeodomain Proteins","In Situ Hybridization","Morphogenesis","Mutation","Oryzias","PAX6 Transcription Factor","Paired Box Transcription Factors","Plant Proteins","Repressor Proteins","Retina","Temperature"],"mesh_terms":["Eye","Brain","Retina","Animals","Oryzias","DNA-Binding Proteins","Homeodomain Proteins","Eye Proteins","Drosophila Proteins","Plant Proteins","Repressor Proteins","In Situ Hybridization","Temperature","Cell Division","Apoptosis","Gene Expression Regulation, Developmental","Morphogenesis","Body Patterning","Genes, Recessive","Mutation","Paired Box Transcription Factors","PAX6 Transcription Factor"],"keywords":["Biology","Optic vesicle","Neuroectoderm","Optic cup (embryology)","Eye development","Morphogenesis","Neurulation","Primordium","Cell biology","Retinal","Retina","PAX6","Mutant","Neural plate","Mutation","Anatomy","Embryogenesis","Genetics","Embryonic stem cell","Gene","Neuroscience","Embryo","Phenotype","Mesoderm","Gastrulation","Biochemistry","Transcription factor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T17:58:53.254198Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}