{"doi":"10.1242/dev.125.2.225","title":"<i>her</i>, a gene required for sexual differentiation in <i>Drosophila</i>, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>The zygotic function of the hermaphrodite (her) gene of Drosophila plays an important role in sexual differentiation. Our molecular genetic characterization of her suggests that her is expressed sex non-specifically and independently of other known sex determination genes and that it acts together with the last genes in the sex determination hierarchy, doublesex and intersex, to control female sexual differentiation. Consistent with such a terminal function in sexual differentiation, her encodes a protein with C2H2-type zinc fingers. The her zinc fingers are atypical and similar to the even-numbered zinc fingers of ZFY and ZFX proteins in humans and other vertebrates.</jats:p>","journal":"Development","year":1998,"id":630557,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1506091,"name":"Bruce S. 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Consistent with such a terminal function in sexual differentiation, her encodes a protein with C2H2-type zinc fingers. The her zinc fingers are atypical and similar to the even-numbered zinc fingers of ZFY and ZFX proteins in humans and other vertebrates.</jats:p>","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9486796","pmcid":null,"openalex_id":"https://openalex.org/W2158673125","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"HD07249-13","title":null}],"total_grants":1,"fwci":0.3917,"citation_percentile":0.65867542,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1/","oa_locations":[{"url":"https://journals.biologists.com/dev/article-pdf/125/2/225/3136205/develop_125_2_225.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.125.2.225","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9486796","host_type":"repository"}],"fields_of_study":["Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Sexual Differentiation and Disorders","Gender Studies in Language"],"mesh_terms":["Abdominal Muscles","Amino Acid Sequence","Animals","Base Sequence","Chromosome Mapping","Cloning, Molecular","DNA-Binding Proteins","Drosophila","Female","Male","Molecular Sequence Data","Nerve Tissue Proteins","RNA Splicing","RNA, Messenger","Sex Differentiation","Transcription Factors","Helminth Proteins","Zinc Fingers","Genes, Insect","Sequence Analysis, DNA","Gene Expression Regulation, Developmental","Insect Proteins","Sex Determination Processes","Drosophila Proteins","Caenorhabditis elegans Proteins","Animals, Genetically Modified"],"keywords":["Biology","Doublesex","Sexual differentiation","Zinc finger","Gene","Genetics","Hermaphrodite","Transcription factor","Zoology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Gender equality"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T21:38:19.934936Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}