{"doi":"10.1242/dev.114.3.555","title":"Molecular analysis of the deletion mutants in the E homeotic complex of the silkworm Bombyx mori","abstract":"ABSTRACT\n The E loci in Bombyx mori are expected to contain a homeotic gene complex specifying the identities of the larval abdominal segments. However, the molecular structure of this complex remains to be determined. We have started to analyze the structural changes in the E complex mutations. We used three newly isolated Bombyx homeobox genes as probes. These genes are probably homologues of the Ultrabiihorax (Ubx), ab-dominal-A (abd-A) and Abdominal-B (Abd-B) in the Drosophila bithorax complex, because the amino-acid sequences of the homeobox regions in these Bombyx genes are almost identical to those of Drosophila genes. We found that the Bombyx Ubx and abd-A genes are deleted in the Eca chromosome, and the Bombyx abd-A gene is deleted in the chromosome. From these results, we conclude that the Bombyx E complex consists of the Ubx, abd-A and possibly Abd-B genes, which may play similar roles to their homologues in the Drosophila bithorax complex.","journal":"Development","year":1992,"id":588519,"datarank":5.270455826548401,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":4.633181540240997,"self_endowment_contribution":0.637274286307404,"citer_contribution":4.633181540240997,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":67,"citers_with_citation_signal":63,"citers_with_endowment":63,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1505604,"name":"Chi-Chung Hui","orcid":null,"position":1,"is_corresponding":false},{"id":183450,"name":"Masakazu Fukuta","orcid":null,"position":2,"is_corresponding":false},{"id":210651,"name":"Yoshiaki Suzuki","orcid":null,"position":3,"is_corresponding":false},{"id":210649,"name":"Kohji Ueno","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Molecular analysis of the deletion mutants in the E homeotic complex of the silkworm Bombyx mori","abstract":"ABSTRACT\n The E loci in Bombyx mori are expected to contain a homeotic gene complex specifying the identities of the larval abdominal segments. However, the molecular structure of this complex remains to be determined. We have started to analyze the structural changes in the E complex mutations. We used three newly isolated Bombyx homeobox genes as probes. These genes are probably homologues of the Ultrabiihorax (Ubx), ab-dominal-A (abd-A) and Abdominal-B (Abd-B) in the Drosophila bithorax complex, because the amino-acid sequences of the homeobox regions in these Bombyx genes are almost identical to those of Drosophila genes. We found that the Bombyx Ubx and abd-A genes are deleted in the Eca chromosome, and the Bombyx abd-A gene is deleted in the chromosome. From these results, we conclude that the Bombyx E complex consists of the Ubx, abd-A and possibly Abd-B genes, which may play similar roles to their homologues in the Drosophila bithorax complex.","is_dataset_classified":null,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1352236","pmcid":null,"openalex_id":"https://openalex.org/W2108114953","authors":[],"funders":[],"total_grants":0,"fwci":9.1589,"citation_percentile":0.98800714,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":3},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1/","oa_locations":[{"url":"https://journals.biologists.com/dev/article-pdf/114/3/555/2763153/develop_114_3_555.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.114.3.555","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1352236","host_type":"repository"}],"fields_of_study":["Silk-based biomaterials and applications","Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Developmental Biology and Gene Regulation","Amino Acid Sequence","Animals","Base Sequence","Blotting, Southern","Bombyx","Chromosome Deletion","Cloning, Molecular","DNA","Genes, Homeobox","Molecular Sequence Data","Mutation","Phenotype","Polymerase Chain Reaction","Sequence Homology, Nucleic Acid"],"mesh_terms":["Amino Acid Sequence","Animals","Base Sequence","Chromosome Deletion","Cloning, Molecular","DNA","Genes, Homeobox","Molecular Sequence Data","Mutation","Phenotype","Sequence Homology, Nucleic Acid","Bombyx","Blotting, Southern","Polymerase Chain Reaction"],"keywords":["Ultrabithorax","Homeotic gene","Biology","Bombyx mori","Homeobox","Genetics","Bombyx","Gene","Hox gene","Mutant","Transcription factor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-21T10:20:36.958189Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}