{"doi":"10.1242/dev.112.4.1053","title":"The <i>Msh</i>-like homeobox genes define domains in the developing vertebrate eye","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>The mouse Hox-7.1 gene has previously been shown to be related to the Drosophila Msh homeobox-containing gene. Here we report the isolation of a new member of this family which resides at an unlinked chromosomal location and has been designated Hox-8.1. Both Hox-7.1 and Hox-8.1 are expressed in the mouse embryo during the early stages of eye development in a distinct spatial and temporal relationship. Hox-8.1 is expressed in the surface ectoderm and in the optic vesicle before invagination occurs in regions corresponding to the prospective corneal epithelium and neural retina, respectively. Hox-7.1 is expressed after formation of the optic cup, marking the domain that will give rise to the ciliary body. The activity of these genes indicates that the inner layer of the optic cup is differentiated into three distinct compartments before overt cellular differentiation occurs. Our results suggest that these genes are involved in defining the region that gives rise to the inner layer of the optic cup and in patterning this tissue to define the iris, ciliary body and retina.</jats:p>","journal":"Development","year":1991,"id":23456,"datarank":13.238736435584118,"base_score":5.375278407684165,"endowment":5.375278407684165,"self_citation_contribution":0.8062917611526249,"citation_network_contribution":12.432444674431492,"self_endowment_contribution":0.8062917611526249,"citer_contribution":12.432444674431492,"corpus_percentile":null,"corpus_rank":null,"citation_count":215,"citer_count":200,"citers_with_citation_signal":190,"citers_with_endowment":190,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":142045,"name":"Duncan R. Davidson","orcid":null,"position":1,"is_corresponding":false},{"id":143963,"name":"Christina Sime","orcid":null,"position":2,"is_corresponding":false},{"id":143964,"name":"Elizabeth Graham","orcid":null,"position":3,"is_corresponding":false},{"id":60563,"name":"Richard Baldock","orcid":"0000-0003-0332-6877","position":4,"is_corresponding":false},{"id":143965,"name":"Shomi S. Bhattacharya","orcid":null,"position":5,"is_corresponding":false},{"id":142046,"name":"Robert E. Hill","orcid":null,"position":6,"is_corresponding":false},{"id":143961,"name":"A. Paula Monaghan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.375278407684165,"endowment":5.375278407684165,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1682128","pmcid":null,"openalex_id":"https://openalex.org/W1826330550","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MC_U127527203","title":null}],"total_grants":1,"fwci":7.7953,"citation_percentile":0.98148891,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":3},{"year":2014,"count":4},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2023,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.biologists.com/user-licence-1-1/","oa_locations":[{"url":"https://journals.biologists.com/dev/article-pdf/112/4/1053/3042146/develop_112_4_1053.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.112.4.1053","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1682128","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Wnt/β-catenin signaling in development and cancer","Ubiquitin and proteasome pathways","Amino Acid Sequence","Animals","Base Sequence","Ciliary Body","Cornea","Eye","Genes, Homeobox","Mice","Molecular Sequence Data","Morphogenesis","Ocular Physiological Phenomena","Retina","Vertebrates"],"mesh_terms":["Amino Acid Sequence","Animals","Base Sequence","Ciliary Body","Cornea","Eye","Genes, Homeobox","Molecular Sequence Data","Morphogenesis","Ocular Physiological Phenomena","Retina","Vertebrates","Mice"],"keywords":["Hox gene","Biology","Homeobox","Optic vesicle","Eye development","Optic cup (embryology)","Retina","Ectoderm","Cell biology","Ciliary body","Genetics","Gene","Anatomy","Embryogenesis","Embryo","Transcription factor","Neuroscience"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.16909578.v1","title":"Additional file 1 of Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.16909578","title":"Additional file 1 of Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T19:31:29.366373Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}