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Furthermore, Numb is needed in the lateral but not adPN or vPN lineages to prevent the appearance of ectopic neuroblasts and to ensure proper self-renewal of neural progenitors. These lineage-specific outputs of Notch/Numb signaling show that a universal mechanism of binary fate decision can be utilized to govern diverse neural sibling differentiations.</jats:p>","journal":"Development","year":2010,"id":669479,"datarank":0.6456097639806255,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":0.0,"self_endowment_contribution":0.6456097639806255,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420466,"name":"Sen-Lin Lai","orcid":"0000-0002-7531-283X","position":1,"is_corresponding":false},{"id":1748471,"name":"Huang-Hsiang Yu","orcid":null,"position":2,"is_corresponding":false},{"id":1007684,"name":"Takahiro Chihara","orcid":"0000-0001-9989-3619","position":3,"is_corresponding":false},{"id":199262,"name":"Liqun Luo","orcid":null,"position":4,"is_corresponding":false},{"id":486404,"name":"Tzumin Lee","orcid":"0000-0003-0569-0111","position":5,"is_corresponding":false},{"id":1748470,"name":"Suewei Lin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the <i>Drosophila</i> brain","abstract":"<jats:p>Numb can antagonize Notch signaling to diversify the fates of sister cells. 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These lineage-specific outputs of Notch/Numb signaling show that a universal mechanism of binary fate decision can be utilized to govern diverse neural sibling differentiations.</jats:p>","is_dataset_classified":null,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20023159","pmcid":"PMC2796933","openalex_id":"https://openalex.org/W2049533330","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH080739","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS042049","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH80739","title":null},{"funder_name":"NIDCD NIH HHS","grant_id":"R01 DC005982","title":null},{"funder_name":"NIDCD NIH HHS","grant_id":"DC005982","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS42049","title":null}],"total_grants":6,"fwci":2.1999,"citation_percentile":0.86675916,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":6},{"year":2014,"count":6},{"year":2015,"count":8},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":8},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://journals.biologists.com/dev/article-pdf/137/1/43/1212557/43.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.041699","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20023159","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2796933","host_type":"repository"}],"fields_of_study":["Neurobiology and Insect Physiology Research","Developmental Biology and Gene Regulation","Plant Molecular Biology Research"],"mesh_terms":["Animals","Brain","Drosophila","Immunohistochemistry","Juvenile Hormones","Models, Biological","Nerve Tissue Proteins","Neurons","Signal Transduction","Apoptosis","Gene Expression Regulation, Developmental","Drosophila Proteins","POU Domain Factors","Receptors, Notch"],"keywords":["NUMB","Biology","Neuroblast","Notch signaling pathway","Lineage (genetic)","Cell fate determination","Embryonic stem cell","Neurogenesis","Neural stem cell","Cell biology","Progenitor cell","Proneural genes","Genetics","Neuroscience","Stem cell","Signal transduction","Transcription factor","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Peace, Justice and strong institutions"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-14T18:17:50.695887Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}