{"doi":"10.1242/dev.02552","title":"BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites","abstract":"<jats:p>Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MOREembryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MOREembryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development.</jats:p>","journal":"Development","year":2006,"id":603338,"datarank":0.6010999777848708,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":0.0,"self_endowment_contribution":0.6010999777848708,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547737,"name":"Shannon Davis","orcid":null,"position":1,"is_corresponding":false},{"id":191458,"name":"John Klingensmith","orcid":null,"position":2,"is_corresponding":false},{"id":75986,"name":"Yuji Mishina","orcid":"0000-0002-6268-4204","position":3,"is_corresponding":false},{"id":123120,"name":"Shigeto Miura","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites","abstract":"<jats:p>Bmpr1a encodes the BMP type IA receptor for bone morphogenetic proteins (BMPs), including 2 and 4. Here, we use mosaic inactivation of Bmpr1a in the epiblast of the mouse embryo (Bmpr-MOREembryos) to assess functions of this gene in mesoderm development. Unlike Bmpr1a-null embryos, which fail to gastrulate, Bmpr-MOREembryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development.</jats:p>","is_dataset_classified":null,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16943278","pmcid":null,"openalex_id":"https://openalex.org/W2170973231","authors":[],"funders":[{"funder_name":"NIDCR NIH HHS","grant_id":"R01DE013674","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"P01HD39948","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":3,"fwci":1.3507,"citation_percentile":0.79544648,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":5},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":4},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":7},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://journals.biologists.com/dev/article-pdf/133/19/3767/1543119/3767.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.02552","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16943278","host_type":"repository"}],"fields_of_study":["Pluripotent Stem Cells Research","Developmental Biology and Gene Regulation","Congenital heart defects research"],"mesh_terms":["Animals","Fibroblast Growth Factors","Mesoderm","Mice, Mutant Strains","Signal Transduction","Somites","Bone Morphogenetic Proteins","Body Patterning","Embryonic Development","Mice","Receptor, Fibroblast Growth Factor, Type 1","Bone Morphogenetic Protein Receptors, Type I"],"keywords":["Paraxial mesoderm","Epiblast","Mesoderm","Biology","Primitive streak","Intermediate mesoderm","FGF and mesoderm formation","Gastrulation","NODAL","Lateral plate mesoderm","Germ layer","Cell biology","Embryogenesis","Genetics","Embryo","Embryonic stem cell","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T21:39:45.351857Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}