{"doi":"10.1242/dev.00426","title":"A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of<i>Drosophila</i>","abstract":"<jats:p>Su(H)/CBF1 is a key component of the evolutionary conserved Notchsignalling pathway. It is a transcription factor that acts as a repressor in the absence of the Notch signal. If Notch signalling is activated, it associates with the released intracellular domain of the Notchreceptor and acts as an activator of transcription. During the development of the mechanosensory bristles of Drosophila, a selection process called lateral inhibition assures that only a few cells are selected out of a group to become sensory organ precursors (SOP). During this process, the SOP cell is thought to suppress the same fate in its surrounding neighbours via the activation of the Notch/Su(H) pathway in these cells. We show that, although Su(H) is required to prevent the SOP fate during lateral inhibition, it is also required to promote the further development of the SOP once it is selected. Importantly, in this situation Su(H) appears to act independently of the Notch signalling pathway. We find that loss of Su(H)function leads to an arrest of SOP development because of the loss ofsens expression in the SOP. Our results suggest that Su(H) acts as a repressor that suppresses the activity of one or more negative regulator(s) ofsens expression. We show that this repressor activity is encoded by one or several genes of the E(spl)-complex. Our results further suggest that the position of the SOP in a proneural cluster is determined by very precise positional cues, which render the SOP insensitive to Dl.</jats:p>","journal":"Development","year":2003,"id":684363,"datarank":0.5983476069846413,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":0.0,"self_endowment_contribution":0.5983476069846413,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":173737,"name":"Thomas Klein","orcid":null,"position":1,"is_corresponding":false},{"id":1787894,"name":"Stefan Koelzer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of<i>Drosophila</i>","abstract":"<jats:p>Su(H)/CBF1 is a key component of the evolutionary conserved Notchsignalling pathway. It is a transcription factor that acts as a repressor in the absence of the Notch signal. If Notch signalling is activated, it associates with the released intracellular domain of the Notchreceptor and acts as an activator of transcription. During the development of the mechanosensory bristles of Drosophila, a selection process called lateral inhibition assures that only a few cells are selected out of a group to become sensory organ precursors (SOP). During this process, the SOP cell is thought to suppress the same fate in its surrounding neighbours via the activation of the Notch/Su(H) pathway in these cells. We show that, although Su(H) is required to prevent the SOP fate during lateral inhibition, it is also required to promote the further development of the SOP once it is selected. Importantly, in this situation Su(H) appears to act independently of the Notch signalling pathway. We find that loss of Su(H)function leads to an arrest of SOP development because of the loss ofsens expression in the SOP. Our results suggest that Su(H) acts as a repressor that suppresses the activity of one or more negative regulator(s) ofsens expression. We show that this repressor activity is encoded by one or several genes of the E(spl)-complex. Our results further suggest that the position of the SOP in a proneural cluster is determined by very precise positional cues, which render the SOP insensitive to Dl.</jats:p>","is_dataset_classified":null,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12642500","pmcid":null,"openalex_id":"https://openalex.org/W2101144251","authors":[],"funders":[],"total_grants":0,"fwci":1.8445,"citation_percentile":0.84899922,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2023,"count":1},{"year":2024,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://journals.biologists.com/dev/article-pdf/130/9/1973/1145676/1973.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1242/dev.00426","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12642500","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Retinal Development and Disorders","Neurobiology and Insect Physiology Research","Animals","Disintegrins","Drosophila","Drosophila Proteins","Membrane Proteins","Metalloendopeptidases","Mutation","Proteins","Receptors, Notch","Repressor Proteins","Thorax","Wings, Animal"],"mesh_terms":["Animals","Drosophila","Membrane Proteins","Metalloendopeptidases","Mutation","Proteins","Repressor Proteins","Thorax","Wings, Animal","Disintegrins","Drosophila Proteins","Receptors, Notch"],"keywords":["Hairless","Biology","Notch signaling pathway","Repressor","Transcription factor","Cell biology","Notch proteins","Cell fate determination","Bristle","Regulator","Proneural genes","Lateral inhibition","Transcription (linguistics)","Genetics","Activator (genetics)","Gene","Signal transduction"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.26641186.v1","title":"Additional file 1 of The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26641186","title":"Additional file 1 of The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T13:54:35.870648Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}