{"doi":"10.1242/bio.059625","title":"Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the <i>Drosophila</i> ovary","abstract":"Stem cells cycle between periods of quiescence and proliferation to promote tissue health. In Drosophila ovaries, quiescence to proliferation transitions of follicle stem cells (FSCs) are exquisitely feeding-dependent. Here, we demonstrate feeding-dependent induction of follicle cell differentiation markers, eyes absent (Eya) and castor (Cas) in FSCs, a patterning process that does not depend on proliferation induction. Instead, FSCs extend micron-scale cytoplasmic projections that dictate Eya-Cas patterning. We identify still life and sickie as necessary and sufficient for FSC projection growth and Eya-Cas induction. Our results suggest that sequential, interdependent events establish long-term differentiation patterns in follicle cell precursors, independently of FSC proliferation induction.","journal":"Biology Open","year":2022,"id":287930,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":933742,"name":"Daniel Zinshteyn","orcid":"0000-0002-1294-4469","position":1,"is_corresponding":false},{"id":968856,"name":"Fred Miglo","orcid":null,"position":2,"is_corresponding":false},{"id":761382,"name":"Melissa Wang","orcid":null,"position":3,"is_corresponding":false},{"id":968857,"name":"Jessica Reinach","orcid":null,"position":4,"is_corresponding":false},{"id":968858,"name":"Cindy M. Chau","orcid":null,"position":5,"is_corresponding":false},{"id":968366,"name":"Joseph M. Grosstephan","orcid":"0000-0002-1485-247X","position":6,"is_corresponding":false},{"id":760728,"name":"Iliana Correa","orcid":"0000-0002-9893-4025","position":7,"is_corresponding":false},{"id":968859,"name":"Kelly Costa","orcid":null,"position":8,"is_corresponding":false},{"id":968860,"name":"Alberto M. Vargas","orcid":null,"position":9,"is_corresponding":false},{"id":968367,"name":"Aminah Johnson","orcid":"0000-0001-6521-4323","position":10,"is_corresponding":false},{"id":968368,"name":"Sheila M. Longo","orcid":"0000-0002-2687-0464","position":11,"is_corresponding":false},{"id":710297,"name":"Jennifer I. Alexander","orcid":"0000-0002-8333-6225","position":12,"is_corresponding":false},{"id":241845,"name":"Alana M. O’Reilly","orcid":"0000-0002-6770-8623","position":13,"is_corresponding":false},{"id":760729,"name":"Eric H. Lee","orcid":"0000-0002-0335-6956","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":null,"created_at":"2026-07-19T00:30:11.069895Z","pmid":"36524613","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}