{"doi":"10.1212/wnl.56.11.1445","title":"Early development of intractable epilepsy in children","abstract":null,"journal":"Neurology","year":2001,"id":645031,"datarank":0.890630430762364,"base_score":5.937536205082426,"endowment":5.937536205082426,"self_citation_contribution":0.890630430762364,"citation_network_contribution":0.0,"self_endowment_contribution":0.890630430762364,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":378,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1679340,"name":"S. Shinnar","orcid":null,"position":1,"is_corresponding":false},{"id":1679341,"name":"S.R. Levy","orcid":null,"position":2,"is_corresponding":false},{"id":1679342,"name":"F.M. Testa","orcid":null,"position":3,"is_corresponding":false},{"id":1679343,"name":"S. Smith–Rapaport","orcid":null,"position":4,"is_corresponding":false},{"id":1679344,"name":"B. Beckerman","orcid":null,"position":5,"is_corresponding":false},{"id":1679339,"name":"A.T. Berg","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Early development of intractable epilepsy in children","abstract":"BACKGROUND: Little is known about early prediction of intractable epilepsy (IE) in children. Such information could help guide the early use of new therapies in selected patients. METHODS: Children with newly diagnosed epilepsy (n = 613) were prospectively identified from child neurology practices in Connecticut (1993--1997) and followed-up for the occurrence of IE (failure of > or = 2 drugs, > or = 1 seizure/month, over 18 months) [corrected]. Etiology and epilepsy syndromes were classified per International League Against Epilepsy guidelines. RESULTS: The median follow-up is 4.8 years, and 599 (97.7%) have been followed for more than 18 months. Sixty children (10.0%) have met the criteria for IE, including 34.6% with cryptogenic/symptomatic generalized, 2.7% with idiopathic, 10.7% with other localization-related, and 8.2% with unclassified epilepsy (p < 0.0001). After multivariable adjustment for epilepsy syndrome, initial seizure frequency (p < 0.0001), focal EEG slowing (p = 0.02), and acute symptomatic or neonatal status epilepticus (p = 0.001) were associated with an increased risk of IE, and age at onset between 5 and 9 years was associated with a lowered risk (p = 0.03). The absolute number of seizures and unprovoked or febrile status epilepticus were not associated substantially with IE. CONCLUSIONS: Approximately 10% of children meet criteria for IE early in the course of their epilepsy. Cryptogenic/symptomatic generalized syndromes carry the highest risk and idiopathic syndromes the lowest. Half of IE occurs in children with nonidiopathic localization-related syndromes. Initial seizure frequency is highly predictive of IE. By contrast, absolute number of seizures and unprovoked or febrile status epilepticus are not.","is_dataset_classified":null,"base_score":5.937536205082426,"endowment":5.937536205082426,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11402099","pmcid":null,"openalex_id":"https://openalex.org/W2049800034","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS31146","title":null}],"total_grants":1,"fwci":7.1911,"citation_percentile":0.97906602,"influential_citations":0,"citation_trend":[{"year":2012,"count":24},{"year":2013,"count":23},{"year":2014,"count":26},{"year":2015,"count":24},{"year":2016,"count":14},{"year":2017,"count":10},{"year":2018,"count":16},{"year":2019,"count":10},{"year":2020,"count":12},{"year":2021,"count":13},{"year":2022,"count":12},{"year":2023,"count":10},{"year":2024,"count":14},{"year":2025,"count":10},{"year":2026,"count":8}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.neurology.org/doi/pdfdirect/10.1212/WNL.56.11.1445","host_type":"publisher"},{"url":"https://doi.org/10.1212/wnl.56.11.1445","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11402099","host_type":"repository"}],"fields_of_study":["Epilepsy research and treatment","EEG and Brain-Computer Interfaces","Psychosomatic Disorders and Their Treatments","Age of Onset","Anticonvulsants","Child","Child, Preschool","Electroencephalography","Female","Follow-Up Studies","Humans","Infant","Male","Multivariate Analysis","Predictive Value of Tests","Prognosis","Prospective Studies","Risk Factors","Seizures, Febrile","Status Epilepticus","Treatment Failure"],"mesh_terms":["Anticonvulsants","Child","Child, Preschool","Seizures, Febrile","Electroencephalography","Female","Follow-Up Studies","Humans","Infant","Male","Predictive Value of Tests","Prognosis","Prospective Studies","Risk Factors","Status Epilepticus","Multivariate Analysis","Treatment Failure","Age of Onset"],"keywords":["Epilepsy","Status epilepticus","Medicine","Pediatrics","Epilepsy syndromes","Etiology","Neurology","Electroencephalography","Generalized epilepsy","Epilepsy in children","Internal medicine","Psychiatry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T02:39:13.247159Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}