{"doi":"10.1210/jendso/bvaf154","title":"Evidence for Functional Ovarian Hyperandrogenism in Early Pubertal, but Not Late Pubertal, Girls With Excess Weight","abstract":"Abstract Context Sources of androgen overproduction in peripubertal girls with overweight/obesity (excess weight [EW]) remain unclear. Objective To assess 17-hydroxyprogesterone (17-OHP) responses to recombinant human chorionic gonadotropin (r-hCG) in peripubertal girls with and without EW. We hypothesized that 17-OHP responses are exaggerated in late pubertal girls with EW compared to those without EW, but similar in early pubertal girls with and without EW. Methods This cross-sectional study conducted at an academic clinical research unit included 45 girls ages 7 to 18 years: 6 early pubertal (Tanner 1-3) with EW and 8 without; 20 late pubertal (Tanner 4-5) with EW and 11 without. Research volunteers took oral dexamethasone (1 mg) at 22:00 hours on study days 1 and 2. On study day 2, volunteers had blood withdrawal at 08:00 hours and r-hCG administration (25 mcg intravenously) at 09:00 hours, with repeat blood withdrawal at 09:00 hours on study day 3; the 17-OHP increment was analyzed. Results 17-OHP responsiveness was 2.31-fold (95% CI, 1.13-4.73) greater in early pubertal girls with EW compared to those without (Bonferroni-corrected P = .023), while responses were similar between late pubertal girls with and without EW. 17-OHP responsiveness in late pubertal girls with EW were 59% (95% CI, 9%-81%) lower than early pubertal girls with EW (Bonferroni-corrected P = .027), while responses were similar between late and early pubertal girls without EW. Conclusion Ovarian responsiveness to r-hCG stimulation during early puberty may be exaggerated in the setting of EW, but excess-weight status per se may not promote long-term ovarian hyperresponsiveness to r-hCG.","journal":"Journal of the Endocrine Society","year":2025,"id":554283,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9607,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323870,"name":"Christopher R. McCartney","orcid":"0000-0002-5421-4982","position":1,"is_corresponding":false},{"id":1249678,"name":"Su Hee Kim","orcid":"0000-0003-2530-867X","position":2,"is_corresponding":false},{"id":321685,"name":"James T. Patrie","orcid":"0000-0001-7392-830X","position":3,"is_corresponding":false},{"id":15376,"name":"John C. Marshall","orcid":"0000-0002-7902-6291","position":4,"is_corresponding":false},{"id":1249680,"name":"Christine M Burt Solorzano","orcid":"0000-0002-5990-2995","position":5,"is_corresponding":false},{"id":1452112,"name":"Melissa A Houghton","orcid":null,"position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T02:54:50.112989Z","pmid":"41245156","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}