{"doi":"10.1210/jendso/bvaf147","title":"MEN1-Related Neuroendocrine Tumors Show c-MET Overexpression","abstract":"Context: Approximately 50% to 70% of patients with multiple endocrine neoplasia type 1 (MEN1) die of duodenopancreatic neuroendocrine tumors (NETs). While c-MET inhibitors in combination with antivascular endothelial growth factor therapy have been shown to result in longer progression-free survival in patients with sporadic NETs, data regarding their efficacy in patients with MEN1-related NETs are lacking. Objective: We sought to characterize c-MET expression in MEN1-related NETs and evaluate its association with clinicopathologic characteristics. Methods: Forty-three tumors from 22 genetically confirmed patients with MEN1-related metastatic NETs were identified. Of these, 15 of 22 (68%) patients had distant metastases while the remaining 7 of 22 had locoregional metastases. Results: c-MET expression was assessed in these tumors via immunohistochemistry. A total of 19 of 43 (44%) were primary tumors (duodenum, pancreas, stomach) while the remaining were metastases. c-MET expression was scored as strongly positive in 3 of 43 (H-score >50), weakly positive in 6 of 43 (H-score: 10-50), and negative in 34 of 43 (H-score <10) tumors. All 3 tumors with strong positive c-MET expression were from patients with a distinctly aggressive clinical course. The 6 tumors with weakly positive c-MET expression were from patients with stable disease, including 4 with distant metastases. Of the 13 patients with all tumors negative for c-MET expression, all but 1 had stable disease. Age at initial NET diagnosis; tumor site, type or grade; number of sites of distant metastases; total number of surgeries for NETs; or the stability of overall tumor burden did not predict c-MET expression. Conclusion: Our findings suggest a role for c-MET inhibition in personalizing therapy for patients with MEN1-related NETs.","journal":"Journal of the Endocrine Society","year":2025,"id":528835,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9638,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1155814,"name":"Dilara Akbulut","orcid":"0000-0003-2288-9667","position":1,"is_corresponding":false},{"id":331822,"name":"William F. Simonds","orcid":"0000-0001-7806-706X","position":2,"is_corresponding":false},{"id":292018,"name":"Lee S. Weinstein","orcid":"0000-0002-1899-5152","position":3,"is_corresponding":false},{"id":352993,"name":"Samira M. Sadowski","orcid":"0000-0002-7538-9431","position":4,"is_corresponding":false},{"id":339670,"name":"Jenny E. Blau","orcid":"0000-0002-6725-4262","position":5,"is_corresponding":false},{"id":474953,"name":"Martha Quezado","orcid":"0009-0004-0941-8662","position":6,"is_corresponding":false},{"id":245220,"name":"Sunita Agarwal","orcid":"0000-0002-7557-3191","position":7,"is_corresponding":false},{"id":331658,"name":"Smita Jha","orcid":"0000-0001-9201-3340","position":8,"is_corresponding":false},{"id":1407126,"name":"Raisa Ghosh","orcid":"0000-0002-1615-3103","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:50:52.565868Z","pmid":"41018051","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}