{"doi":"10.1210/jendso/bvae103","title":"The Influence of Pubertal Development on Autoantibody Appearance and Progression to Type 1 Diabetes in the TEDDY Study","abstract":"Abstract Context The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty. Objective We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes. Methods The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Onset of puberty was determined by subject self-assessment of Tanner stages. Associations between speed of pubertal progression, pubertal growth, weight gain, homeostasis model assessment of insulin resistance (HOMA-IR), islet autoimmunity, and progression to type 1 diabetes were assessed. The influence of individual factors was analyzed using Cox proportional hazard ratios. Results Out of 5677 children who were still in the study at age 8 years, 95% reported at least 1 Tanner Stage score and were included in the study. Children at puberty (Tanner Stage ≥2) had a lower risk (HR 0.65, 95% CI 0.45-0.93; P = .019) for incident autoimmunity than prepubertal children (Tanner Stage 1). An increase of body mass index Z-score was associated with a higher risk (HR 2.88, 95% CI 1.61-5.15; P < .001) of incident insulin autoantibodies. In children with multiple autoantibodies, neither HOMA-IR nor rate of progression to Tanner Stage 4 were associated with progression to type 1 diabetes. Conclusion Rapid weight gain during puberty is associated with development of islet autoimmunity. Puberty itself had no significant influence on the appearance of autoantibodies or type 1 diabetes. Further studies are needed to better understand the underlying mechanisms.","journal":"Journal of the Endocrine Society","year":2024,"id":475776,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9216,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":391573,"name":"Roy Tamura","orcid":null,"position":1,"is_corresponding":false},{"id":506258,"name":"Desmond Schatz","orcid":"0000-0002-1044-5762","position":2,"is_corresponding":false},{"id":414042,"name":"Riitta Veijola","orcid":"0000-0002-6557-270X","position":3,"is_corresponding":false},{"id":96015,"name":"Andrea K. Steck","orcid":"0000-0002-5931-9484","position":4,"is_corresponding":false},{"id":16102,"name":"Beena Akolkar","orcid":"0000-0002-2351-5942","position":5,"is_corresponding":false},{"id":95829,"name":"William Hagopian","orcid":"0000-0003-2979-0475","position":6,"is_corresponding":false},{"id":5970,"name":"Jeffrey P. Krischer","orcid":"0000-0003-4526-888X","position":7,"is_corresponding":false},{"id":95837,"name":"Åke Lernmark","orcid":"0000-0003-1735-0499","position":8,"is_corresponding":false},{"id":95828,"name":"Marian Rewers","orcid":"0000-0003-3829-9207","position":9,"is_corresponding":false},{"id":95830,"name":"Jorma Toppari","orcid":"0000-0003-2228-334X","position":10,"is_corresponding":false},{"id":678216,"name":"Richard McIndoe","orcid":"0000-0002-3040-3631","position":11,"is_corresponding":false},{"id":71711,"name":"Anette‐G. Ziegler","orcid":null,"position":12,"is_corresponding":false},{"id":95834,"name":"Kendra Vehik","orcid":"0000-0001-6243-6772","position":13,"is_corresponding":false},{"id":356520,"name":"Michael J. Haller","orcid":"0000-0002-2803-1824","position":14,"is_corresponding":false},{"id":414044,"name":"Helena Elding Larsson","orcid":"0000-0003-3306-1742","position":15,"is_corresponding":false},{"id":873924,"name":"Katharina Warncke","orcid":"0000-0003-1758-7656","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T02:06:21.071690Z","pmid":"38867880","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}