{"doi":"10.1210/jendso/bvae064","title":"Spatial Transcriptomic Analysis of Pituitary Corticotroph Tumors","abstract":"Context: Spatial transcriptomic (ST) analysis of tumors provides a novel approach to studying gene expression along with the localization of tumor cells in their environment to uncover spatial interactions. Design: We present ST analysis of corticotroph pituitary neuroendocrine tumors (PitNETs) from formalin-fixed, paraffin-embedded tissues. ST data were compared to immunohistochemistry results. Gene expression profiles were reviewed for cluster annotations, and differentially expressed genes were used for pathway analysis. Results: Seven tumors were used for ST analysis. In situ annotation of tumor tissue was inferred from the gene expression profiles and was in concordance with the annotation made by a pathologist. Furthermore, relative gene expression in the tumor corresponded to common protein staining used in the evaluation of PitNETs, such as reticulin and Ki-67 index. Finally, we identified intratumor heterogeneity; clusters within the same tumor may present with different transcriptomic profiles, unveiling potential intratumor cell variability. Conclusion: Together, our results provide the first attempt to clarify the spatial cell profile in PitNETs.","journal":"Journal of the Endocrine Society","year":2024,"id":459380,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6323,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356392,"name":"Fábio R. Faucz","orcid":"0000-0001-7959-9842","position":1,"is_corresponding":false},{"id":1175523,"name":"Cameron Padilla","orcid":"0009-0001-9962-6008","position":2,"is_corresponding":false},{"id":683609,"name":"Charalampos S. Floudas","orcid":"0000-0002-0020-237X","position":3,"is_corresponding":false},{"id":356394,"name":"Prashant Chittiboina","orcid":"0000-0001-9349-4756","position":4,"is_corresponding":false},{"id":474953,"name":"Martha Quezado","orcid":"0009-0004-0941-8662","position":5,"is_corresponding":false},{"id":395177,"name":"Christina Tatsi","orcid":"0000-0002-2882-4584","position":6,"is_corresponding":false},{"id":1037017,"name":"Jeremie D. Oliver","orcid":"0000-0003-3387-5770","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:03:55.280882Z","pmid":"38633897","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}