{"doi":"10.1210/jcem-47-3-543","title":"Gastric Inhibitory Polypeptide in Acquired Pancreatic Diabetes: Effects of Insulin Treatment*","abstract":null,"journal":"The Journal of Clinical Endocrinology & Metabolism","year":1978,"id":600063,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1538175,"name":"AARON I. VINIK","orcid":null,"position":1,"is_corresponding":false},{"id":1538176,"name":"PATRICIA T. CHILD","orcid":null,"position":2,"is_corresponding":false},{"id":1538174,"name":"JOHANNES L. BOTHA","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gastric Inhibitory Polypeptide in Acquired Pancreatic Diabetes: Effects of Insulin Treatment*","abstract":"Oral glucose tolerance tests were done in eight insulin-requiring pancreatic diabetic patients to study the effect of withdrawal of insulin treatment on gut hormone release. Basal levels of gastric inhibitory polypeptide (GIP), glucagon-like immunoreactivity, and immunoreactive glucagon levels rose on insulin withdrawal, more so in patients on short-acting insulin, and were lowered by insulin treatment. Insulin treatment did not affect the GIP, glucagon-like immunoreactivity, or IRG responses to oral glucose. Improved glucose tolerance was greater in patients receiving soluble insulin than in those receiving lente insulin, and there was a significant positive linear correlation between basal plasma GIP and blood glucose levels in these patients. Therefore, it is suggested that insulin treatment lowers basal hormones levels, possibly via a metabolic effect, whereas the hormone responses to oral glucose may be controlled by several factors unrelated to insulin administration or changes in glucose homeostasis.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"400725","pmcid":null,"openalex_id":"https://openalex.org/W2068166803","authors":[],"funders":[],"total_grants":0,"fwci":1.2723,"citation_percentile":0.78213665,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/jcem/article-pdf/47/3/543/10512728/jcem0543.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1210/jcem-47-3-543","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/400725","host_type":"repository"}],"fields_of_study":["Diabetes Treatment and Management","Helicobacter pylori-related gastroenterology studies","Pancreatic function and diabetes"],"mesh_terms":["Adolescent","Adult","Blood Glucose","Chronic Disease","Diabetes Mellitus","Gastric Inhibitory Polypeptide","Gastrointestinal Hormones","Glucagon","Glucose Tolerance Test","Humans","Insulin","Middle Aged","Pancreatitis"],"keywords":["Internal medicine","Endocrinology","Insulin","Basal (medicine)","Glucagon","Hormone","Glucose homeostasis","Diabetes mellitus","Gastric inhibitory polypeptide","Medicine","Homeostasis","Insulin resistance"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T12:08:05.273417Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}