{"doi":"10.1210/jcem-23-3-279","title":"Ring D-α-Ketols as Metabolic Products of Estrogen in the Nonpregnant Human1","abstract":null,"journal":"The Journal of Clinical Endocrinology & Metabolism","year":1963,"id":617889,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1593646,"name":"R. HOBKIRK","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ring D-α-Ketols as Metabolic Products of Estrogen in the Nonpregnant Human1","abstract":"Estriol, ring D—α-ketols and estrone were measured in the urine of 9 normal males aged 17–50 yr, and 12 postmenopausal females, aged 47–72 yr. Mean values (μg/24 hr) with ranges were as follows: Males: estriol, 8.3 (3.9–13.5); ring D—α-ketols, 5.6 (2.3–10.1); estrone, 5.0 (1.5–8.3). Females: estriol, 6.0 (1.5–14.9); ring D—α-ketols, 2.8 (1.3–4.2); estrone, 2.2 (0.4–4.9). The ring D—α-ketolic fraction appears to consist, on the average, of approximately equal amounts of 16α-hydroxyestrone and a 16-ketoestradiol-17β(16-ketoestradiol) fraction perhaps containing some 16β-hydroxyestrone. Analysis of C14—ring D—α-ketols from the urine of 3 subjects given estrone-16-C14 suggests that 16α-hydroxyestrone and the 16-ketoestradiol fraction arise from estrone, perhaps via some common intermediate. No proof could be obtained for the conversion in vivo of 16-ketoestradiol to 16α-hydroxyestrone, either directly or via the triols.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"13954882","pmcid":null,"openalex_id":"https://openalex.org/W2093596392","authors":[],"funders":[],"total_grants":0,"fwci":1.883,"citation_percentile":0.86692131,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/jcem/article-pdf/23/3/279/10532776/jcem0279.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1210/jcem-23-3-279","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/13954882","host_type":"repository"}],"fields_of_study":["Estrogen and related hormone effects","Cholesterol and Lipid Metabolism","Diet, Metabolism, and Disease","Contraceptive Agents, Female","Estradiol Congeners","Estriol","Estrogens","Estrone","Female","Humans","Indoles"],"mesh_terms":["Contraceptive Agents, Female","Estriol","Estrogens","Estrone","Female","Humans","Indoles","Estradiol Congeners"],"keywords":["Estrone","Estriol","Estrogen","Ring (chemistry)","Urine","Chemistry","Endocrinology","Internal medicine","Medicine","Organic chemistry","Biochemistry","Estrogens","Indoles"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:52:09.232289Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}