{"doi":"10.1210/jc.2009-2057","title":"Height Adjustment in Assessing Dual Energy X-Ray Absorptiometry Measurements of Bone Mass and Density in Children","abstract":null,"journal":"The Journal of Clinical Endocrinology &amp; Metabolism","year":2010,"id":600127,"datarank":0.9167201009254019,"base_score":6.111467339502679,"endowment":6.111467339502679,"self_citation_contribution":0.9167201009254019,"citation_network_contribution":0.0,"self_endowment_contribution":0.9167201009254019,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":450,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417333,"name":"Mary B. Leonard","orcid":"0000-0002-8972-6582","position":1,"is_corresponding":false},{"id":32955,"name":"Andrea Kelly","orcid":"0000-0003-1724-9868","position":2,"is_corresponding":false},{"id":45181,"name":"Joan M. Lappe","orcid":"0000-0001-8274-2515","position":3,"is_corresponding":false},{"id":45185,"name":"Vicente Gilsanz","orcid":"0000-0001-5898-4901","position":4,"is_corresponding":false},{"id":1538361,"name":"Sharon Oberfield","orcid":null,"position":5,"is_corresponding":false},{"id":1538363,"name":"Soroosh Mahboubi","orcid":null,"position":6,"is_corresponding":false},{"id":1538364,"name":"John A. Shepherd","orcid":null,"position":7,"is_corresponding":false},{"id":1094741,"name":"Thomas N. Hangartner","orcid":null,"position":8,"is_corresponding":false},{"id":1538366,"name":"Margaret M. Frederick","orcid":null,"position":9,"is_corresponding":false},{"id":298528,"name":"Karen K. Winer","orcid":"0000-0001-8261-5188","position":10,"is_corresponding":false},{"id":45180,"name":"Heidi J. Kalkwarf","orcid":"0000-0001-9030-8401","position":11,"is_corresponding":false},{"id":45189,"name":"Babette S. Zemel","orcid":"0000-0002-6164-7348","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Height Adjustment in Assessing Dual Energy X-Ray Absorptiometry Measurements of Bone Mass and Density in Children","abstract":"<h4>Context</h4>In children, bone mineral content (BMC) and bone mineral density (BMD) measurements by dual-energy x-ray absorptiometry (DXA) are affected by height status. No consensus exists on how to adjust BMC or BMD (BMC/BMD) measurements for short or tall stature.<h4>Objective</h4>The aim of this study was to compare various methods to adjust BMC/BMD for height in healthy children.<h4>Design</h4>Data from the Bone Mineral Density in Childhood Study (BMDCS) were used to develop adjustment methods that were validated using an independent cross-sectional sample of healthy children from the Reference Data Project (RDP).<h4>Setting</h4>We conducted the study in five clinical centers in the United States.<h4>Participants</h4>We included 1546 BMDCS and 650 RDP participants (7 to 17 yr of age, 50% female).<h4>Intervention</h4>No interventions were used.<h4>Main outcome measures</h4>We measured spine and whole body (WB) BMC and BMD Z-scores for age (BMC/BMD(age)), height age (BMC/BMD(height age)), height (BMC(height)), bone mineral apparent density (BMAD(age)), and height-for-age Z-score (HAZ) (BMC/BMD(haz)).<h4>Results</h4>Spine and WB BMC/BMD(age)Z and BMAD(age)Z were positively (P < 0.005; r = 0.11 to 0.64) associated with HAZ. Spine BMD(haz) and BMC(haz)Z were not associated with HAZ; WB BMC(haz)Z was modestly associated with HAZ (r = 0.14; P = 0.0003). All other adjustment methods were negatively associated with HAZ (P < 0.005; r = -0.20 to -0.34). The deviation between adjusted and BMC/BMD(age) Z-scores was associated with age for most measures (P < 0.005) except for BMC/BMD(haz).<h4>Conclusions</h4>Most methods to adjust BMC/BMD Z-scores for height were biased by age and/or HAZ. Adjustments using HAZ were least biased relative to HAZ and age and can be used to evaluate the effect of short or tall stature on BMC/BMD Z-scores.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20103654","pmcid":"PMC2841534","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"K24 DK076808","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"N01-HD-1-3333","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"UL1-RR024134","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"UL1 RR024134","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"N01-HD-1-3228","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"N01-HD-1-3329","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"N01-HD-1-3332","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"M01 RR000240","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"N01-HD-1-3330","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"N01-HD-1-3331","title":null}],"total_grants":10,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/jcem/article-pdf/95/3/1265/9067379/jcem1265.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/jcem/article-pdf/95/3/1265/9067379/jcem1265.pdf","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2841534","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Bone and Bones","Humans","Absorptiometry, Photon","Body Height","Regression Analysis","Cross-Sectional Studies","Adolescent Development","Child Development","Age Factors","Sex Factors","Bone Density","Reference Values","Adolescent","Child","Female","Male"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T12:17:42.391744Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}