{"doi":"10.1210/endocr/bqaf019","title":"Integration of Glucagon-Like Peptide 1 Receptor Actions Through the Central Amygdala","abstract":"Understanding the detailed mechanism of action of glucagon-like peptide 1 receptor (GLP-1R) agonists on distinct topographic and genetically defined brain circuits is critical for improving the efficacy and mitigating adverse side effects of these compounds. In this mini-review, we propose that the central nucleus of the amygdala (CeA) is a critical mediator of GLP-1R agonist-driven hypophagia. Here, we review the extant literature demonstrating CeA activation via GLP-1R agonists across multiple species and through multiple routes of administration. The precise role of GLP-1Rs within the CeA is unclear but the site-specific GLP-1Rs may mediate distinct behavioral and physiological hallmarks of GLP-1R agonists on food intake. Thus, we propose important novel directions and methods to test the role of the CeA in mediating GLP-1R actions.","journal":"Endocrinology","year":2025,"id":515678,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1005240,"name":"J Willis","orcid":"0000-0003-0087-4296","position":1,"is_corresponding":false},{"id":1380585,"name":"Nilay Dalvi","orcid":null,"position":2,"is_corresponding":false},{"id":1379994,"name":"Zoe N. Fokakis","orcid":"0000-0002-9138-8252","position":3,"is_corresponding":false},{"id":1379995,"name":"SONJA VIRKUS","orcid":"0000-0003-2300-3901","position":4,"is_corresponding":false},{"id":1379996,"name":"J. Andrew Hardaway","orcid":"0000-0003-3893-2658","position":5,"is_corresponding":false},{"id":1379993,"name":"Miguel Duran","orcid":"0000-0002-2746-1291","position":0,"is_corresponding":true}],"reference_count":205,"raw_metadata":null,"created_at":"2026-07-19T02:48:39.436300Z","pmid":"39888375","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}