{"doi":"10.1210/endocr/bqaf004","title":"Gut Microbiome Regulation of Gut Hormone Secretion","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The gut microbiome, comprising bacteria, viruses, fungi, and bacteriophages, is one of the largest microbial ecosystems in the human body and plays a crucial role in various physiological processes. This review explores the interaction between the gut microbiome and enteroendocrine cells (EECs), specialized hormone-secreting cells within the intestinal epithelium. EECs, which constitute less than 1% of intestinal epithelial cells, are key regulators of gut–brain communication, energy metabolism, gut motility, and satiety. Recent evidence shows that gut microbiota directly influence EEC function, maturation, and hormone secretion. For instance, commensal bacteria regulate the production of hormones like glucagon-like peptide 1 and peptide YY by modulating gene expression and vesicle cycling in EE cells. Additionally, metabolites such as short-chain fatty acids, derived from microbial fermentation, play a central role in regulating EEC signaling pathways that affect metabolism, gut motility, and immune responses. Furthermore, the interplay between gut microbiota, EECs, and metabolic diseases, such as obesity and diabetes, is examined, emphasizing the microbiome's dual role in promoting health and contributing to disease states. This intricate relationship between the gut microbiome and EECs offers new insights into potential therapeutic strategies for metabolic and gut disorders.</jats:p>","journal":"Endocrinology","year":2025,"id":656512,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1713788,"name":"Rosemary A Coleman","orcid":null,"position":1,"is_corresponding":false},{"id":234838,"name":"Damien J. Keating","orcid":"0000-0002-0154-8305","position":2,"is_corresponding":false},{"id":234832,"name":"Alyce M. Martin","orcid":"0000-0003-1631-8307","position":3,"is_corresponding":false},{"id":1713787,"name":"Jessica Chao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gut Microbiome Regulation of Gut Hormone Secretion","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The gut microbiome, comprising bacteria, viruses, fungi, and bacteriophages, is one of the largest microbial ecosystems in the human body and plays a crucial role in various physiological processes. This review explores the interaction between the gut microbiome and enteroendocrine cells (EECs), specialized hormone-secreting cells within the intestinal epithelium. EECs, which constitute less than 1% of intestinal epithelial cells, are key regulators of gut–brain communication, energy metabolism, gut motility, and satiety. Recent evidence shows that gut microbiota directly influence EEC function, maturation, and hormone secretion. For instance, commensal bacteria regulate the production of hormones like glucagon-like peptide 1 and peptide YY by modulating gene expression and vesicle cycling in EE cells. Additionally, metabolites such as short-chain fatty acids, derived from microbial fermentation, play a central role in regulating EEC signaling pathways that affect metabolism, gut motility, and immune responses. Furthermore, the interplay between gut microbiota, EECs, and metabolic diseases, such as obesity and diabetes, is examined, emphasizing the microbiome's dual role in promoting health and contributing to disease states. This intricate relationship between the gut microbiome and EECs offers new insights into potential therapeutic strategies for metabolic and gut disorders.</jats:p>","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40037297","pmcid":"PMC11879239","openalex_id":"https://openalex.org/W4408128787","authors":[],"funders":[{"funder_name":"Alyce Martin from the Australian Research Council","grant_id":"DE220100403","title":"Discovery Early Career Researcher Award - Grant ID: DE220100403"}],"total_grants":1,"fwci":14.5592,"citation_percentile":0.99418394,"influential_citations":1,"citation_trend":[{"year":2025,"count":17},{"year":2026,"count":20}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/endo/article-pdf/166/4/bqaf004/62211808/bqaf004.pdf","host_type":"journal"},{"url":"https://academic.oup.com/endo/article-pdf/166/4/bqaf004/62211808/bqaf004.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1210/endocr/bqaf004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40037297","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11879239","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11879239","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1210/endocr/bqaf004","host_type":""}],"fields_of_study":["Gut microbiota and health","Diet and metabolism studies","Dietary Effects on Health","Medicine","Biology","0301 basic medicine","03 medical and health sciences"],"mesh_terms":["Gastrointestinal Microbiome","Animals","Gastrointestinal Hormones","Humans","Intestinal Mucosa","Enteroendocrine Cells"],"keywords":["Gut microbiome","Endocrinology","Internal medicine","Microbiome","Hormone","Secretion","Biology","Medicine","Bioinformatics","Enteroendocrine Cells","Gut Hormone","Host Physiology","Gastrointestinal Hormones","Humans","Animals","Mini-Review","Intestinal Mucosa","Gastrointestinal Microbiome"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T21:07:03.115580Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}