{"doi":"10.1210/endocr/bqad137","title":"Influence of Vitamin D Deficiency on Cyclin D1-Induced Parathyroid Tumorigenesis","abstract":"Primary hyperparathyroidism (PHPT) is a common endocrinopathy for which several pathogenic mechanisms, including cyclin D1 overexpression, have been identified. Vitamin D nutritional status may influence parathyroid tumorigenesis, but evidence remains circumstantial. To assess the potential influence of vitamin D insufficiency/deficiency on initiation or progression of parathyroid tumorigenesis, we superimposed vitamin D insufficiency or deficiency on parathyroid tumor-prone parathyroid hormone-cyclin D1 transgenic mice. Mice were placed on diets containing either 2.75 IU/g, 0.25 IU/g, or 0.05 IU/g cholecalciferol, either prior to expected onset of PHPT or after onset of biochemical PHPT. When introduced early, superimposed vitamin D insufficiency/deficiency had no effect on serum calcium or on parathyroid gland growth. However, when introduced after the onset of biochemical PHPT, vitamin D deficiency led to larger parathyroid glands without differences in serum biochemical parameters. Our results suggest that low vitamin D status enhances proliferation of parathyroid cells whose growth is already being tumorigenically driven, in contrast to its apparent lack of direct proliferation-initiating action on normally growing parathyroid cells in this model. These results are consistent with the hypothesis that suboptimal vitamin D status may not increase incidence of de novo parathyroid tumorigenesis but may accelerate growth of a preexisting parathyroid tumor.","journal":"Endocrinology","year":2023,"id":375524,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9586,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":391832,"name":"Kristin Corrado","orcid":null,"position":1,"is_corresponding":false},{"id":391833,"name":"Justin Bellizzi","orcid":null,"position":2,"is_corresponding":false},{"id":391834,"name":"Elizabeth A. Saria","orcid":null,"position":3,"is_corresponding":false},{"id":391835,"name":"Kirsten Saucier","orcid":null,"position":4,"is_corresponding":false},{"id":1138520,"name":"Miriam Güemes-Aragon","orcid":null,"position":5,"is_corresponding":false},{"id":1138521,"name":"Guntas Kakar","orcid":null,"position":6,"is_corresponding":false},{"id":391174,"name":"Madison M. Rose","orcid":"0000-0003-3827-3330","position":7,"is_corresponding":false},{"id":1138522,"name":"Melanie Pascal","orcid":null,"position":8,"is_corresponding":false},{"id":391837,"name":"Cynthia Alander","orcid":null,"position":9,"is_corresponding":false},{"id":391175,"name":"Sanjay M. Mallya","orcid":"0000-0002-2244-9939","position":10,"is_corresponding":false},{"id":391176,"name":"Andrew Arnold","orcid":"0000-0002-8821-8527","position":11,"is_corresponding":false},{"id":391172,"name":"Jessica Costa‐Guda","orcid":"0000-0001-6437-1693","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:16:23.381203Z","pmid":"37694586","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}