{"doi":"10.1210/endocr/bqab031","title":"microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3","abstract":"Pancreatic β-cell dysfunction is central to the development and progression of type 2 diabetes. Dysregulation of microRNAs (miRNAs) has been associated with pancreatic islet dysfunction in type 2 diabetes. Previous study has shown that miR-483 is expressed relatively higher in β-cells than in α-cells. To explore the physiological function of miR-483, we generated a β-cell-specific knockout mouse model of miR-483. Loss of miR-483 enhances high-fat diet-induced hyperglycemia and glucose intolerance by the attenuation of diet-induced insulin release. Intriguingly, mice with miR-483 deletion exhibited loss of β-cell features, as indicated by elevated expression of aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), a marker of β-cell dedifferentiation. Moreover, Aldh1a3 was validated as a direct target of miR-483 and overexpression of miR-483 repressed Aldh1a3 expression. Genetic ablation of miR-483 also induced alterations in blood lipid profile. Collectively, these data suggest that miR-483 is critical in protecting β-cell function by repressing the β-cell disallowed gene Aldh1a3. The dysregulated miR-483 may impair insulin secretion and initiate β-cell dedifferentiation during the development of type 2 diabetes.","journal":"Endocrinology","year":2021,"id":175124,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9466,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":480687,"name":"Ramkumar Mohan","orcid":"0000-0002-1308-1642","position":1,"is_corresponding":false},{"id":715484,"name":"Xinqian Chen","orcid":"0000-0002-8558-9250","position":2,"is_corresponding":false},{"id":716196,"name":"Katy Matson","orcid":null,"position":3,"is_corresponding":false},{"id":716197,"name":"Jackson Waugh","orcid":null,"position":4,"is_corresponding":false},{"id":715485,"name":"Yiping Mao","orcid":"0009-0004-0553-4172","position":5,"is_corresponding":false},{"id":444128,"name":"Shungang Zhang","orcid":"0000-0002-6668-7453","position":6,"is_corresponding":false},{"id":715486,"name":"Wanzhen Li","orcid":"0009-0007-8287-4762","position":7,"is_corresponding":false},{"id":156370,"name":"Xiaohu Tang","orcid":null,"position":8,"is_corresponding":false},{"id":348735,"name":"Leslie S. Satin","orcid":"0000-0003-1355-8647","position":10,"is_corresponding":false},{"id":715487,"name":"Xiaoqing Tang","orcid":"0000-0002-3039-806X","position":11,"is_corresponding":false},{"id":715483,"name":"Zhihong Wang","orcid":"0000-0002-5836-8073","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:47:11.249697Z","pmid":"33564883","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}