{"doi":"10.1210/endo.141.9.7633","title":"Dietary Protein Restriction Lowers Plasma Insulin-Like Growth Factor I (IGF-I), Impairs Cortical Bone Formation, and Induces Osteoblastic Resistance to IGF-I in Adult Female Rats<sup>1</sup>","abstract":null,"journal":"Endocrinology","year":2000,"id":657858,"datarank":3.810298319316945,"base_score":4.875197323201151,"endowment":4.875197323201151,"self_citation_contribution":0.7312795984801728,"citation_network_contribution":3.079018720836772,"self_endowment_contribution":0.7312795984801728,"citer_contribution":3.079018720836772,"corpus_percentile":null,"corpus_rank":null,"citation_count":130,"citer_count":97,"citers_with_citation_signal":71,"citers_with_endowment":71,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1717311,"name":"P. Ammann","orcid":null,"position":1,"is_corresponding":false},{"id":1717312,"name":"J. P. Bonjour","orcid":null,"position":2,"is_corresponding":false},{"id":1717313,"name":"R. Rizzoli","orcid":null,"position":3,"is_corresponding":false},{"id":1717310,"name":"S. Bourrin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dietary Protein Restriction Lowers Plasma Insulin-Like Growth Factor I (IGF-I), Impairs Cortical Bone Formation, and Induces Osteoblastic Resistance to IGF-I in Adult Female Rats<sup>1</sup>","abstract":"Dietary protein deficiency, common in elderly, is associated with decreased areal bone mineral density and plasma insulin-like growth factor I (IGF-I). To investigate the early adaptation of bone cells to protein restriction, 6-month-old female rats were pair-fed with isocaloric 15% (control) or 2.5% casein diets for 14 days. Animals were then treated daily with rhIGF-I/IGFBP-3 (1:4, 2.5 mg IGF-I/kg BW) or with vehicle for 10 days. After double-labeling, proximal metaphysis and mid-diaphysis of the tibia were analyzed histomorphometrically. Plasma osteocalcin, IGF-I, and urinary deoxypyridinoline were quantified. After 14 days of protein restriction, significant drops in plasma osteocalcin (13%) and IGF-I (37%), in periosteal formation (83%) and mineral apposition (49%) rates are observed, indicating a decreased osteoblast recruitment and activity. In cancellous bone, a significant decrease in active eroded surfaces (27%) and osteoclast number (24%) indicates a transient depression of resorption. In rats fed the 15% casein diet, rhIGF-I/IGFBP-3 increases cancellous (42%) and periosteal (600%) formation rates, indicating an increased osteoblast recruitment. In protein-restricted rats, rhIGF-I/IGFBP-3 fails to increase cancellous or periosteal bone formation and plasma osteocalcin is significantly lower than in 15% casein+rhIGF-I/ IGFBP-3 rats. Protein restriction induces osteoblast resistance to rhIGF-I/IGFBP-3 in both bone envelopes. Low plasma IGF-I and osteoblast resistance to IGF-I, may contribute to the impaired periosteal formation.","is_dataset_classified":null,"base_score":4.875197323201151,"endowment":4.875197323201151,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10965885","pmcid":null,"openalex_id":"https://openalex.org/W2049146993","authors":[],"funders":[],"total_grants":0,"fwci":4.1438,"citation_percentile":0.94203165,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":8},{"year":2014,"count":10},{"year":2015,"count":5},{"year":2016,"count":6},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/endo/article-pdf/141/9/3149/10361581/endo3149.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/endo/article-pdf/141/9/3149/10361581/endo3149.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1210/endo.141.9.7633","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10965885","host_type":"repository"}],"fields_of_study":["Growth Hormone and Insulin-like Growth Factors","Bone health and osteoporosis research","Muscle metabolism and nutrition","Animals","Biomarkers","Body Weight","Bone Development","Bone Resorption","Bone and Bones","Diet","Dietary Proteins","Drug Resistance","Female","Insulin-Like Growth Factor Binding Protein 3","Insulin-Like Growth Factor I","Organ Size","Osteoblasts","Rats","Rats, Sprague-Dawley","Recombinant Proteins"],"mesh_terms":["Animals","Body Weight","Bone and Bones","Bone Development","Bone Resorption","Diet","Dietary Proteins","Drug Resistance","Female","Insulin-Like Growth Factor I","Organ Size","Osteoblasts","Recombinant Proteins","Biomarkers","Rats, Sprague-Dawley","Insulin-Like Growth Factor Binding Protein 3","Rats"],"keywords":["Endocrinology","Internal medicine","Osteoblast","Osteocalcin","Cancellous bone","Deoxypyridinoline","Osteoclast","Chemistry","Metaphysis","Bone resorption","Bone growth","Insulin-like growth factor","Growth factor","Biology","Medicine","Alkaline phosphatase","Anatomy","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:33:24.689961Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}