{"doi":"10.1210/clinem/dgaf663","title":"Implementation of a Spanish-language, direct-to-patient primary aldosteronism testing program","abstract":"CONTEXT: Primary aldosteronism (PA) is a common, targetable cause of hypertension and cardiovascular risk, but <2% of eligible patients are tested, and Hispanic/Latino patients are underrepresented in PA research and care. OBJECTIVE: We expanded a nationwide, direct-to-patient PA testing program to reach Spanish-speaking adults. METHODS: Spanish-speaking adults with PA testing indications were recruited from Boston, New York, Miami, Houston, and Los Angeles/San Diego. Participants underwent virtual medical history review in Spanish and local phlebotomy for PA testing, with laboratory interpretations communicated to patients and clinicians. Participants were followed up at 6 months. The primary outcome was the frequency of a positive PA test. Secondary outcomes included clinical PA testing, initiation of aldosterone-targeted therapies, and quality of life. RESULTS: The study population (N = 155) spoke fluent Spanish, with 77.4% reporting limited English proficiency. Of the participants, 30.3% tested positive for PA. Leading PA testing indications were family history of premature hypertension or stroke and sleep apnea. Among participants who tested positive and provided follow-up (n = 29), 10.3% underwent additional testing for PA, and 10.3% started a mineralocorticoid receptor antagonist. Participants cited access to care and clinician dismissal of results as barriers to clinical action; however, study participation was positively rated to enhance health awareness and interest in research participation. CONCLUSION: This Spanish-language, direct-to-patient PA testing program effectively reached patients for testing, identified possible PA in over 30%, and influenced downstream care. Language-concordant PA testing initiatives can help to address the high prevalence of hypertension and PA in the US Hispanic/Latino population.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2025,"id":537494,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7156,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1205369,"name":"Laura C Tsai","orcid":"0009-0008-5344-2589","position":1,"is_corresponding":false},{"id":1423727,"name":"E Abel","orcid":null,"position":2,"is_corresponding":false},{"id":1423728,"name":"Kristen Foote","orcid":null,"position":3,"is_corresponding":false},{"id":729665,"name":"Andrew J Newman","orcid":"0000-0002-8326-1964","position":4,"is_corresponding":false},{"id":1354887,"name":"Stéfanie Parisien‐La Salle","orcid":"0000-0001-5960-4181","position":5,"is_corresponding":false},{"id":1366878,"name":"Cheng‐Hsuan Tsai","orcid":"0000-0003-2859-5117","position":6,"is_corresponding":false},{"id":263020,"name":"Anand Vaidya","orcid":"0000-0002-0314-9252","position":7,"is_corresponding":false},{"id":301182,"name":"Jenifer M. Brown","orcid":"0000-0002-6647-639X","position":8,"is_corresponding":false},{"id":1423296,"name":"Arnaldo Ferrebus","orcid":"0009-0009-0558-2154","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:52:12.997494Z","pmid":"41370229","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}