{"doi":"10.1210/clinem/dgaf519","title":"Adverse Outcomes in Patients With Hypothyroidism Undergoing Bariatric Surgery: A Retrospective Study Using TriNetX","abstract":"CONTEXT: Bariatric surgery (BS) effectively reduces obesity-related risks, but its outcomes in patients with preexisting hypothyroidism are unclear. OBJECTIVE: To evaluate the impact of preexisting hypothyroidism on adverse health outcomes following BS. METHODS: In this retrospective cohort study utilizing the TriNetX Global Collaborative Network database, patients with obesity who underwent BS or not, with and without hypothyroidism, were propensity score-matched. Short-term outcomes comprised mortality, readmission, ICU admission, and surgical and systemic complications. Long-term outcomes included mortality, major adverse events, bone health, and metabolic, renal, and neurological outcomes. RESULTS: There were 5700 patients in each cohort (46.7 ± 12 years, 88% female). In the short term, patients with hypothyroidism exhibited higher risks of readmission (risk ratio [RR]: 1.25; CI: 1.14-1.36), incisional hernia (RR: 1.56; CI: 1.12-2.18), and biliary diseases (RR: 1.39; CI: 1.05-1.86). In the long term, patients with hypothyroidism had higher risks of incident cerebrovascular events (hazard ratio [HR]: 1.25; CI: 1.00-1.55), diabetes (HR: 1.39; CI: 1.12-1.74), and dyslipidemia (HR: 1.20; CI: 1.02-1.42). There were also higher risks of fall (HR: 1.20; CI: 1.02-1.40), osteoporosis (HR: 1.30; CI: 1.07-1.58), polyneuropathy (HR: 1.34; CI: 1.08-1.66), hypoglycemia (HR: 1.51; CI: 1.23-1.87), as well as iron (HR: 1.17; CI: 1.04-1.31) and vitamin B (HR: 1.34; CI: 1.20-1.49) deficiencies. Hypothyroidism-associated risks of poor outcomes were higher in patients who underwent gastric bypass. Compared to the nonsurgical care, patients with hypothyroidism who underwent BS showed a lower risk of obesity-related outcomes but a higher risk of iron and vitamin B deficiencies, osteoporosis, and hypoglycemia. CONCLUSION: Preexisting hypothyroidism in bariatric patients increases the risks of adverse outcomes. However, the risk of obesity-related outcomes is decreased in this population when compared to nonsurgical care.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2025,"id":526909,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8864,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1403043,"name":"Fabyan Esberard de Lima Beltrão","orcid":"0000-0001-9713-2584","position":1,"is_corresponding":false},{"id":275501,"name":"George Golovko","orcid":"0000-0003-4609-2767","position":2,"is_corresponding":false},{"id":1403044,"name":"Riley K Watson","orcid":"0000-0003-0242-6091","position":3,"is_corresponding":false},{"id":1403045,"name":"Sarah Samreen","orcid":"0000-0002-2096-7468","position":4,"is_corresponding":false},{"id":302143,"name":"Matthew D Ettleson","orcid":"0000-0003-0328-1752","position":5,"is_corresponding":false},{"id":42485,"name":"Isabela M. Benseñor","orcid":"0000-0002-6723-5678","position":6,"is_corresponding":false},{"id":254116,"name":"Antônio C. Bianco","orcid":"0000-0001-7737-6813","position":7,"is_corresponding":false},{"id":1403042,"name":"Vandrize Meneghini","orcid":"0000-0002-2787-6841","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:50:34.851930Z","pmid":"40971953","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}