{"doi":"10.1210/clinem/dgaf460","title":"Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans","abstract":"CONTEXT: Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent. OBJECTIVE: We aimed to assess the association between osteocalcin and type 2 diabetes-related QTs and the roles of adipokines on the association between OC and glucose metabolism. METHODS: We used data from the BetaGene study, which is a cross-sectional family-based study of Mexican Americans from Los Angeles County. We tested the association between type 2 diabetes-related QTs and OC, including inactive (OC-inactive) and active (OC-active) forms, in 867 Mexican Americans without type 2 diabetes from 342 families. We also assessed the potential mediating effect of adipokines on these relationships. RESULTS: OC-active was negatively associated with insulin sensitivity (SI; P = 2.1 × 10-3) and positively associated with the insulinogenic index (P = 2.8 × 10-3). Acute insulin response was marginally significantly associated with OC-active (P = .07). Measures of β-cell compensation for insulin resistance were not associated with OC. There was no evidence of mediation by adipokines. CONCLUSION: We conclude OC-active is associated with SI, without mediation by adipokines or body fat. As there was no association with measures of β-cell compensation for insulin resistance, the association between OC-active and insulin secretion reflects the compensatory response to SI.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2025,"id":534412,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1152619,"name":"Vera Hsu","orcid":null,"position":1,"is_corresponding":false},{"id":1417011,"name":"Alyson Kil","orcid":"0000-0001-5851-4870","position":2,"is_corresponding":false},{"id":1417559,"name":"Michael Arias","orcid":null,"position":3,"is_corresponding":false},{"id":1417012,"name":"Hetian Chen","orcid":"0000-0003-4505-403X","position":4,"is_corresponding":false},{"id":524897,"name":"Enrique Trigo","orcid":null,"position":5,"is_corresponding":false},{"id":1396098,"name":"Adrienne W. MacKay","orcid":null,"position":6,"is_corresponding":false},{"id":370816,"name":"Anny H. Xiang","orcid":"0000-0003-2786-1268","position":7,"is_corresponding":false},{"id":506642,"name":"Thomas A. Buchanan","orcid":"0000-0001-7892-5132","position":8,"is_corresponding":false},{"id":90144,"name":"Richard M. Watanabe","orcid":"0000-0003-1015-0531","position":9,"is_corresponding":false},{"id":1417010,"name":"Yumeng Gao","orcid":"0009-0000-8171-8011","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:51:47.434742Z","pmid":"40795894","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}