{"doi":"10.1210/clinem/dgaf448","title":"Dietary Patterns for Weight and Glycemic Management in Persons With Type 1 Diabetes: A Meta-analysis of Clinical Trials","abstract":"BACKGROUND: Medical nutrition therapy is fundamental for managing glycemia and weight in type 1 diabetes, yet dietary guidance specific to this population and relevant subgroups is lacking. PURPOSE: We synthesized the interventional literature investigating diet patterns for glycemic and weight management in youth and adults with type 1 diabetes, with attention to interindividual variation that suggests the need for precision approaches. The protocol was prospectively registered (CRD42024519941). DATA SOURCES: AMED, CINAHL, Cochrane Library, Ovid MEDLINE, Ovid Embase, Google Scholar, and Web of Science Core Collection were searched from January 2011 to June 2024. STUDY SELECTION: Clinical trials ≥4 weeks with ≥10 youth and/or adults diagnosed with type 1 diabetes ≥6 months prior and reporting glycated hemoglobin (HbA1c) or weight were included. DATA SYNTHESIS: Twelve studies with 668 participants were included. Data were pooled by random-effects models for HbA1c and weight. Studies with insufficient data and subgroup differences were narratively synthesized per Synthesis without meta-analysis guidelines. Pooled results of very low to moderate certainty evidence showed no advantage of any particular diet pattern in randomized trials. Very low-quality evidence from single-arm low carbohydrate trials suggested improved HbA1c over time (-0.63% [95% CI, -0.99 to -0.27]; -6.0 mmol/mol [-10.8 to -3.0]). Wide pooled CIs suggested between-person heterogeneity; however, stratification of results by participant characteristics was rarely performed. LIMITATIONS: Limited evidence precluded subgroup analyses to inform precision nutrition approaches. CONCLUSION: Randomized trials are needed to confirm the efficacy of specific diets and determine whether precision nutrition therapies optimize glycemia and weight in persons with type 1 diabetes.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2025,"id":538337,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":449251,"name":"Laura M. Nally","orcid":"0000-0003-4349-4808","position":1,"is_corresponding":false},{"id":528403,"name":"Alyssa Grimshaw","orcid":"0000-0003-3985-0056","position":2,"is_corresponding":false},{"id":528402,"name":"Craig G. Gunderson","orcid":"0000-0001-8220-0249","position":3,"is_corresponding":false},{"id":1058157,"name":"Elizabeth G. Considine","orcid":"0000-0003-1023-8939","position":4,"is_corresponding":false},{"id":506257,"name":"Laura M. Jacobsen","orcid":"0000-0002-5144-7836","position":5,"is_corresponding":false},{"id":513346,"name":"Mustafa Tosur","orcid":"0000-0002-2111-271X","position":6,"is_corresponding":false},{"id":336608,"name":"Peter A. Gottlieb","orcid":"0000-0002-7601-8536","position":7,"is_corresponding":false},{"id":231204,"name":"Irl B. Hirsch","orcid":"0000-0003-1675-8417","position":8,"is_corresponding":false},{"id":280970,"name":"Lori M. Laffel","orcid":"0000-0002-9675-3001","position":9,"is_corresponding":false},{"id":449253,"name":"Jennifer L. Sherr","orcid":"0000-0001-9301-3043","position":10,"is_corresponding":false},{"id":404619,"name":"Chantal Mathieu","orcid":"0000-0002-4055-5233","position":11,"is_corresponding":false},{"id":231670,"name":"Richard E. Pratley","orcid":"0000-0002-2912-1389","position":12,"is_corresponding":false},{"id":746430,"name":"Daria Igudesman","orcid":"0000-0001-5209-4625","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T02:52:21.389196Z","pmid":"40795275","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}