{"doi":"10.1210/clinem/dgae770","title":"The Maturity-Onset Diabetes of the Young (MODY) Calculator Overestimates MODY Probability in Hispanic Youth","abstract":"CONTEXT: The applicability of the maturity-onset diabetes of the young (MODY) risk calculator to non-White European populations remains unknown. OBJECTIVE: We aimed to test its real-world application in Hispanic youth. METHODS: We conducted a retrospective chart review of Hispanic youth (<23 years) with diabetes (n = 2033) in a large pediatric tertiary care center in the United States. We calculated MODY probability for all subjects, splitting them into 2 cohorts based on the original model: individuals who were started on insulin within 6 months of diabetes diagnosis (Cohort 1) and those who were not (Cohort 2). RESULTS: Cohort 1 consisted of 1566 individuals (median age [25p, 75p]: 16 [13, 19] years, 49% female), while Cohort 2 comprised 467 youth (median age [25p, 75p]: 17 [15, 20] years, 62% female). The mean MODY probability was 5.9% and 61.9% in Cohort 1 and Cohort 2, respectively. The mean probability for both cohorts combined was 18.8%, suggesting an expected 382 individuals with MODY, which is much higher than previous estimations (1-5%; ie, 20-102 individuals in this cohort). A total of 18 individuals tested positive for MODY among the limited number of individuals tested based on clinical suspicion and genetic testing availability (n = 44 out of 2033 tested, 2.2% of overall cohort). CONCLUSION: The MODY risk calculator likely overestimates the probability of MODY in Hispanic youth, largely driven by an overestimation in those not early-insulin treated (predominantly young-onset type 2 diabetes). The calculator needs updating to improve its applicability in this population. In addition, further research is needed to help better identify MODY in Hispanic youth.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2024,"id":449505,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8672,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1035639,"name":"Anh Minh Nguyen","orcid":"0009-0001-7754-4167","position":1,"is_corresponding":false},{"id":285364,"name":"Angus G. Jones","orcid":"0000-0002-0883-7599","position":2,"is_corresponding":false},{"id":506259,"name":"Beverley M. Shields","orcid":"0000-0003-3785-327X","position":3,"is_corresponding":false},{"id":7390,"name":"María J. Redondo","orcid":"0000-0001-5871-4645","position":4,"is_corresponding":false},{"id":513346,"name":"Mustafa Tosur","orcid":"0000-0002-2111-271X","position":5,"is_corresponding":false},{"id":1269290,"name":"Guido Alarcon","orcid":"0009-0000-5938-1184","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T02:02:20.585759Z","pmid":"39492690","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}