{"doi":"10.1210/clinem/dgae733","title":"Tumor Volume Doubling Time of Less Than 1 Year Is Associated With a Higher Risk of Death From Medullary Thyroid Cancer","abstract":"CONTEXT: Tumor volume doubling time (TVDT) is emerging as a useful tool in predicting oncologic outcomes. There are limited data on the prognostic role of TVDT in metastatic medullary thyroid cancer (MTC). OBJECTIVE: The goal of this study was to assess the value of TVDT in predicting disease-specific survival (DSS) in patients with hereditary and sporadic MTC. METHODS: This was an Institutional Review Board-approved cohort study including patients with metastatic MTC having at least 3 consecutive imaging studies. TVDT of up to the 5 largest lesions per organ was calculated using a standardized formula. The association between TVDT and DSS was analyzed using Kaplan-Meier survival curves. Cox proportional regression model was used to account for confounding factors. RESULTS: The study sample consisted of 51 patients presenting with 286 metastatic lesions measured with 457 scans during the follow-up of 51 (IQR, 25-102) months. Median age was 19 years (IQR, 15-41), 53% female patients. Cumulative volumes of all metastatic lesions and proportion of patients with TVDT of < 1 year were higher in patients with sporadic as compared with hereditary MTC (P < .01). Factors independently associated with shorter DSS were TVDT of < 1 year based on 3 initial and 3 last scans as well as lung, brain, and prostate as the organs with the fastest growing tumor. TVDT based on 2-dimensional and 3-dimensional measurements showed strong correlation (r = 0.94, P < .05). CONCLUSION: Measurements from 3 baseline and 3 most recent scans preceding follow-up visit enable calculation of TVDT and can be used as predictors of mortality from MTC.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2024,"id":483777,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9427,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1324777,"name":"Anthony Leonardi","orcid":"0000-0002-1865-9597","position":1,"is_corresponding":false},{"id":108961,"name":"Sriram Gubbi","orcid":"0000-0002-9263-1381","position":2,"is_corresponding":false},{"id":503357,"name":"Sonam Kumari","orcid":"0000-0002-6052-9972","position":3,"is_corresponding":false},{"id":1325251,"name":"Mateus Guimarães Pascoal","orcid":null,"position":4,"is_corresponding":false},{"id":1325252,"name":"Ashwin Bharadwaj","orcid":null,"position":5,"is_corresponding":false},{"id":1325253,"name":"Amr Dorgham","orcid":null,"position":6,"is_corresponding":false},{"id":960613,"name":"Elizabeth C. Wright","orcid":"0000-0002-9841-3879","position":7,"is_corresponding":false},{"id":491371,"name":"Tomilowo Abijo","orcid":null,"position":8,"is_corresponding":false},{"id":1325254,"name":"C Vikram","orcid":null,"position":9,"is_corresponding":false},{"id":405591,"name":"Padmasree Veeraraghavan","orcid":null,"position":10,"is_corresponding":false},{"id":207668,"name":"Craig Cochran","orcid":null,"position":11,"is_corresponding":false},{"id":805168,"name":"Srivandana Akshintala","orcid":"0000-0002-3478-9893","position":12,"is_corresponding":false},{"id":109202,"name":"John Glod","orcid":"0000-0002-3071-7876","position":13,"is_corresponding":false},{"id":255444,"name":"Joanna Kłubo-Gwieździńska","orcid":"0000-0001-8633-4420","position":14,"is_corresponding":false},{"id":927885,"name":"Noha Behairy","orcid":"0000-0002-3150-7598","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:07:33.718973Z","pmid":"39412150","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}