{"doi":"10.1210/clinem/dgae645","title":"Obesity Is Associated With Hyperandrogenemia in a Nationally Representative Sample of US Girls Aged 6 to 18 Years","abstract":"CONTEXT: Studies have associated obesity with peripubertal hyperandrogenemia. However, these studies were performed in academic centers and could have been influenced by selection bias. OBJECTIVE: To investigate if free testosterone levels are elevated in peripubertal girls with obesity. DESIGN/SETTING: We analyzed data from the National Health and Nutrition Examination Survey 2013-2016 databases. PARTICIPANTS: 1299 girls aged 6-18 years residing in the United States. MAIN OUTCOME MEASURES: Mean free testosterone concentration (calculated from total testosterone and SHBG). RESULTS: Among girls aged 6 to 9 years, mean (95% confidence interval) free testosterone was 0.33 pg/mL (0.28-0.38) in healthy-weight girls vs 0.86 pg/mL (0.67-1.05) in girls with obesity. Among girls aged 10 to 14 years, free testosterone was 2.29 pg/mL (2.05-2.53) in healthy-weight girls vs 4.10 pg/mL (3.60-4.60) in girls with obesity. Among girls aged 15 to 18 years, free testosterone was 3.33 pg/mL (2.96-3.70) in healthy-weight girls and 5.64 pg/mL (4.93-6.36) in girls with obesity. Girls with obesity in all age groups had higher free testosterone levels compared to healthy-weight girls. In each age group, the 95% confidence intervals for free testosterone did not overlap between healthy weight vs obesity subgroups. A multiple regression model accounted for 42% of the variance in free testosterone (R2 = 0.42), and both weight and age categories were independent predictors of free testosterone (P < .0001 for each). CONCLUSION: In a nationally representative sample of US girls, obesity is associated with elevated free testosterone, suggesting an important relationship between obesity and peripubertal hyperandrogenemia.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2024,"id":439084,"datarank":0.5675660465083489,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.2078817555885932,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.2078817555885932,"corpus_percentile":65.45215440550786,"corpus_rank":4467,"citation_count":10,"citer_count":8,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7215,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1249679,"name":"Aaron Pannone","orcid":"0000-0001-6035-2700","position":1,"is_corresponding":false},{"id":426461,"name":"Mark D. DeBoer","orcid":"0000-0003-1462-591X","position":2,"is_corresponding":false},{"id":323870,"name":"Christopher R. McCartney","orcid":"0000-0002-5421-4982","position":3,"is_corresponding":false},{"id":1249680,"name":"Christine M Burt Solorzano","orcid":"0000-0002-5990-2995","position":4,"is_corresponding":false},{"id":1249678,"name":"Su Hee Kim","orcid":"0000-0003-2530-867X","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:00:47.992543Z","pmid":"39311388","pmcid":"PMC12086398","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}