{"doi":"10.1210/clinem/dgae307","title":"Environmental Phenols and Growth in Infancy: The Infant Feeding and Early Development Study","abstract":"CONTEXT: Higher mean and rapid increases in body mass index (BMI) during infancy are associated with subsequent obesity and may be influenced by exposure to endocrine-disrupting chemicals such as phenols. OBJECTIVE: In a prospective US-based cohort conducted 2010-2014, we investigated associations between environmental phenol exposures and BMI in 199 infants. METHODS: We measured 7 urinary phenols at ages 6-8 and 12 weeks and assessed BMI z-score at up to 12 study visits between birth and 36 weeks. We examined individual and joint associations of averaged early infancy phenols with level of BMI z-score using mean differences (β [95% CI]) and with BMI z-score trajectories using relative risk ratios (RR [95% CI]). RESULTS: Benzophenone-3, methyl and propyl paraben, and all phenols jointly were positively associated with higher mean BMI z-score (0.07 [-0.05, 0.18], 0.10 [-0.08, 0.27], 0.08 [-0.09, 0.25], 0.17 [-0.08, 0.43], respectively). Relative to a stable trajectory, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, and all phenols jointly were positively associated with risk of a rapid increase trajectory (1.46 [0.89, 2.39], 1.33 [0.88, 2.01], 1.66 [1.03, 2.68], 1.41 [0.71, 2.84], respectively). CONCLUSION: Early phenol exposure was associated with a higher mean and rapid increase in BMI z-score across infancy, signaling potential long-term cardiometabolic consequences of exposure.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2024,"id":468018,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8627,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281033,"name":"Mandy Goldberg","orcid":"0000-0002-6794-1206","position":1,"is_corresponding":false},{"id":325487,"name":"Margaret A. Adgent","orcid":"0000-0002-5951-5514","position":2,"is_corresponding":false},{"id":431769,"name":"Helen B. Chin","orcid":"0000-0001-5090-6909","position":3,"is_corresponding":false},{"id":294195,"name":"Donna D. Baird","orcid":"0000-0002-5544-2653","position":4,"is_corresponding":false},{"id":366225,"name":"Virginia A. Stallings","orcid":"0000-0002-7025-7149","position":5,"is_corresponding":false},{"id":104612,"name":"Dale P. Sandler","orcid":"0000-0002-6776-0018","position":6,"is_corresponding":false},{"id":241824,"name":"Antonia M. Calafat","orcid":"0000-0002-9796-7482","position":7,"is_corresponding":false},{"id":433011,"name":"Eileen G. Ford","orcid":null,"position":8,"is_corresponding":false},{"id":489596,"name":"Babette S Zemel","orcid":null,"position":9,"is_corresponding":false},{"id":32955,"name":"Andrea Kelly","orcid":"0000-0003-1724-9868","position":10,"is_corresponding":false},{"id":292086,"name":"David M. Umbach","orcid":"0000-0002-7142-2812","position":11,"is_corresponding":false},{"id":431772,"name":"Walter J. Rogan","orcid":"0000-0002-9302-0160","position":12,"is_corresponding":false},{"id":105710,"name":"Kelly K. Ferguson","orcid":"0000-0001-8467-3250","position":13,"is_corresponding":false},{"id":422442,"name":"Danielle R. Stevens","orcid":"0000-0002-4321-8355","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-19T02:05:19.071498Z","pmid":"38753668","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}