{"doi":"10.1210/clinem/dgad587","title":"The Vitamin D Metabolite Ratio Is Associated With Volumetric Bone Density in Older Men","abstract":"CONTEXT: Serum 25-hydroxyvitamin D (25(OH)D) is the current marker of vitamin D adequacy, but its relationship with bone health has been inconsistent. The ratio of 24,25-dihydroxyvitamin D3 to 25(OH)D3 (vitamin D metabolite ratio or VMR) is a marker of vitamin D that has been associated with longitudinal changes in bone mineral density (BMD) and fracture risk. OBJECTIVE: High-resolution peripheral quantitative computed tomography (HR-pQCT) provides information on bone health beyond standard dual-energy x-ray absorptiometry, in that it measures volumetric BMD (vBMD) as well bone strength. The relationship of the VMR with vBMD and bone strength remains unknown. METHODS: We evaluated the associations of the VMR and 25(OH)D3 with vBMD and bone strength in the distal radius and tibia, assessed by HR-pQCT in 545 older men participating in the Osteoporotic Fractures in Men (MrOS) Study. Primary outcomes were vBMD and estimated failure load (EFL, a marker of bone strength) at the distal radius and tibia. RESULTS: The mean age was 84 ± 4 years, 88.3% were White, and 32% had an estimated glomerular filtration rate <60 mL/min/1.73 m2. In adjusted models, each twofold higher VMR was associated with a 9% (3%, 16%) higher total vBMD and a 13% (5%, 21%) higher EFL at the distal radius. Results were similar at the distal tibia. 25(OH)D3 concentrations were not associated with any of the studied outcomes. CONCLUSION: Among older men, a higher VMR was associated with greater vBMD and bone strength while 25(OH)D3 was not. The VMR may serve as a valuable marker of skeletal health in older men.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2023,"id":377738,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278795,"name":"Terri Blackwell","orcid":"0000-0003-0012-7020","position":1,"is_corresponding":false},{"id":449465,"name":"Jonathan Cheng","orcid":"0000-0002-7278-3409","position":2,"is_corresponding":false},{"id":1058340,"name":"Onur Potok","orcid":"0009-0005-1141-6401","position":3,"is_corresponding":false},{"id":109422,"name":"Jane A. Cauley","orcid":"0000-0003-0752-4408","position":4,"is_corresponding":false},{"id":242503,"name":"Kristine E. Ensrud","orcid":"0000-0002-9069-3036","position":5,"is_corresponding":false},{"id":310801,"name":"Simon Hsu","orcid":"0000-0003-3780-294X","position":6,"is_corresponding":false},{"id":250537,"name":"Deborah M. Kado","orcid":"0000-0002-2582-5573","position":7,"is_corresponding":false},{"id":250536,"name":"Eric Orwoll","orcid":"0000-0002-8520-7355","position":8,"is_corresponding":false},{"id":109435,"name":"Peggy M. Cawthon","orcid":"0000-0003-4938-9478","position":9,"is_corresponding":false},{"id":261907,"name":"Joachim H. Ix","orcid":"0000-0002-8084-9869","position":10,"is_corresponding":false},{"id":323672,"name":"Charles Ginsberg","orcid":"0000-0001-9408-3684","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37804103","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}