{"doi":"10.1210/clinem/dgad390","title":"Changes in Hepatic Fat Content by CT 1 Year After Sleeve Gastrectomy in Adolescents and Young Adults With Obesity","abstract":"CONTEXT: Obesity is associated with nonalcoholic fatty liver disease (NAFLD). Sleeve gastrectomy (SG) is an effective means of weight loss and improvement of NAFLD in adults; however, data regarding the efficacy of SG in the early stages of pediatric NAFLD are sparse. OBJECTIVE: To assess the impact of SG on hepatic fat content 1 year after SG in youth with obesity compared with nonsurgical controls with obesity (NS). DESIGN: A 12-month prospective study in 52 participants (mean age, 18.2 ± .36 years) with obesity, comprising 25 subjects who underwent SG (84% female; median body mass index [BMI], 44.6 [42.1-47.9] kg/m2) and 27 who were NS (70% female; median BMI, 42.2 [38.7-47.0] kg/m2). MAIN OUTCOME MEASURES: Hepatic fat content by computed tomography (liver/spleen ratio), abdominal fat by magnetic resonance imaging. RESULTS: Mean 12-month decrease in BMI was greater in SG vs NS (-12.5 ± .8 vs -.2 ± .5 kg/m2, P < .0001). There was a within-group increase in the liver-to-spleen (L/S) ratio in SG (.13 ± .05, P = .014) but not NS with a trend for a difference between groups (P = .055). All SG participants with an L/S ratio <1.0 (threshold for the diagnosis of NAFLD) before surgery had a ratio of >1.0 a year after surgery, consistent with resolution of NAFLD. Within SG, the 12-month change in L/S ratio was negatively associated with 12-month change in visceral fat (ρ = -.51 P = .016). CONCLUSIONS: Hepatic fat content as assessed by noncontrast computed tomography improved after SG over 1 year in youth with obesity with resolution of NAFLD in all subjects. This was associated with decreases in visceral adiposity.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2023,"id":346328,"datarank":0.5107012733997306,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.12595886978050003,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.12595886978050003,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":9,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9676,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02557438"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1086711,"name":"Shubhangi Tuli","orcid":"0000-0002-7128-7534","position":1,"is_corresponding":false},{"id":944497,"name":"Meghan Lauze","orcid":"0009-0001-5282-8032","position":2,"is_corresponding":false},{"id":1052788,"name":"Imen Becetti","orcid":"0000-0002-3363-7441","position":3,"is_corresponding":false},{"id":935871,"name":"Clarissa C Pedreira","orcid":"0000-0003-1267-3344","position":4,"is_corresponding":false},{"id":1086712,"name":"Florian A. Huber","orcid":"0000-0001-6317-4815","position":5,"is_corresponding":false},{"id":1086713,"name":"Emre Ömeroğlu","orcid":"0000-0002-1662-4382","position":6,"is_corresponding":false},{"id":388581,"name":"Vibha Singhal","orcid":"0000-0002-9729-4433","position":7,"is_corresponding":false},{"id":388582,"name":"Madhusmita Misra","orcid":"0000-0002-9405-2981","position":8,"is_corresponding":false},{"id":314302,"name":"Miriam A. Bredella","orcid":"0000-0001-5482-0440","position":9,"is_corresponding":false},{"id":1086710,"name":"Ana Paola López López","orcid":"0000-0002-1564-0567","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T01:11:48.317335Z","pmid":"37403207","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}