{"doi":"10.1210/clinem/dgad369","title":"Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma?","abstract":"CONTEXT: Total thyroidectomy in pediatric papillary thyroid carcinoma (PTC) is recommended in national guidelines because of the high incidence of multifocal disease (MFD). OBJECTIVE: To determine the incidence of MFD in childhood and adolescent vs adult PTC and whether MFD is a predictor for poorer outcomes in childhood and adolescent PTC. METHODS: We conducted an institutional review board-approved review of patients with PTC undergoing surgery (1986-2021) at Memorial Sloan Kettering Cancer Center. Clinical and pathological characteristics in patients with unifocal disease (UFD) and MFD were compared using Pearson's χ2 test. Survival outcomes were analyzed using the Kaplan-Meier method and log-rank test. Multivariate analysis assessed the impact of MFD on outcome. RESULTS: MFD was less common in childhood and adolescent patients with PTC (45%; 127/283) than in adults (54%; 3023/5564; P = .002). Childhood and adolescent patients with UFD and MFD had similar tumor stage and PTC subtype at presentation, with no significant difference in histopathologic features. Median follow-up was 68 months. There was no significant difference in 5-year recurrence-free probability and overall survival was 100% in both groups. There was no significant difference in 5-year contralateral lobe PTC-free probability between patients with UFD and MFD treated with lobectomy. Multivariate analysis showed MFD was not a predictor for recurrence. CONCLUSION: MFD was less common in childhood and adolescent patients with PTC than adults and was not a predictor of poor outcome on multivariate analysis, with excellent long-term outcomes in all patients with PTC. MFD does not appear to warrant completion thyroidectomy in childhood and adolescent patients selected for lobectomy.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2023,"id":352725,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":968650,"name":"Joseph Lopez","orcid":"0000-0003-3001-1109","position":1,"is_corresponding":false},{"id":969064,"name":"Alana Eagan","orcid":null,"position":2,"is_corresponding":false},{"id":571654,"name":"Zoltan Antal","orcid":"0000-0001-8471-8930","position":3,"is_corresponding":false},{"id":55870,"name":"R. Michael Tuttle","orcid":"0000-0001-9899-9702","position":4,"is_corresponding":false},{"id":13486,"name":"Ronald Ghossein","orcid":"0000-0003-2802-8489","position":5,"is_corresponding":false},{"id":106473,"name":"Michael P. LaQuaglia","orcid":"0000-0002-7059-9851","position":6,"is_corresponding":false},{"id":519310,"name":"Ashok R. Shaha","orcid":"0000-0001-7478-9436","position":7,"is_corresponding":false},{"id":385578,"name":"Jatin P. Shah","orcid":"0000-0002-6444-6592","position":8,"is_corresponding":false},{"id":255806,"name":"Richard J. Wong","orcid":"0000-0001-6259-7314","position":9,"is_corresponding":false},{"id":291699,"name":"Snehal G. Patel","orcid":"0000-0001-9775-5132","position":10,"is_corresponding":false},{"id":267983,"name":"Ian Ganly","orcid":"0000-0001-7636-5426","position":11,"is_corresponding":false},{"id":1099019,"name":"Daniel W. Scholfield","orcid":null,"position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:12:54.209378Z","pmid":"37350510","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}