{"doi":"10.1210/clinem/dgac469","title":"Multicenter Analysis of Cardiometabolic-related Diagnoses in Transgender and Gender-Diverse Youth: A PEDSnet Study","abstract":"CONTEXT: Studies on cardiometabolic health in transgender and gender-diverse youth (TGDY) are limited to small cohorts. OBJECTIVE: This work aimed to determine the odds of cardiometabolic-related diagnoses in TGDY compared to matched controls in a cross-sectional analysis, using a large, multisite database (PEDSnet). METHODS: Electronic health record data (2009-2019) were used to determine odds of cardiometabolic-related outcomes based on diagnosis, anthropometric, and laboratory data using logistic regression among TGDY youth vs controls. The association of gender-affirming hormone therapy (GAHT) with these outcomes was examined separately among TGDY. TGDY (n = 4172) were extracted from 6 PEDSnet sites and propensity-score matched on 8 variables to controls (n = 16 648). Main outcomes measures included odds of having cardiometabolic-related diagnoses among TGDY compared to matched controls, and among TGDY prescribed GAHT compared to those not prescribed GAHT. RESULTS: In adjusted analyses, TGDY had higher odds of overweight/obesity (1.2; 95% CI, 1.1-1.3) than controls. TGDY with a testosterone prescription alone or in combination with a gonadotropin-releasing hormone agonist (GnRHa) had higher odds of dyslipidemia (1.7; 95% CI, 1.3-2.3 and 3.7; 95% CI, 2.1-6.7, respectively) and liver dysfunction (1.5; 95% CI, 1.1-1.9 and 2.5; 95% CI, 1.4-4.3) than TGDY not prescribed GAHT. TGDY with a testosterone prescription alone had higher odds of overweight/obesity (1.8; 95% CI, 1.5-2.1) and hypertension (1.6 95% CI, 1.2-2.2) than those not prescribed testosterone. Estradiol and GnRHa alone were not associated with greater odds of cardiometabolic-related diagnoses. CONCLUSION: TGDY have increased odds of overweight/obesity compared to matched controls. Screening and tailored weight management, sensitive to the needs of TGDY, are needed.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2022,"id":246551,"datarank":1.264884481630494,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.715350234711047,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.715350234711047,"corpus_percentile":83.70851705732188,"corpus_rank":2107,"citation_count":38,"citer_count":33,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6677,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278326,"name":"Shanlee Davis","orcid":"0000-0002-0304-9550","position":1,"is_corresponding":false},{"id":675065,"name":"Anna Furniss","orcid":"0000-0001-5498-607X","position":2,"is_corresponding":false},{"id":282497,"name":"Nadia Dowshen","orcid":"0000-0002-8466-1628","position":3,"is_corresponding":false},{"id":317121,"name":"Anne E. Kazak","orcid":"0000-0003-0553-0855","position":4,"is_corresponding":false},{"id":883170,"name":"Christopher S. Lewis","orcid":"0009-0007-8654-9529","position":5,"is_corresponding":false},{"id":687672,"name":"Danielle F. Loeb","orcid":"0000-0003-1688-8799","position":6,"is_corresponding":false},{"id":385066,"name":"Leena Nahata","orcid":"0000-0003-3899-2642","position":7,"is_corresponding":false},{"id":254435,"name":"Laura Pyle","orcid":"0000-0001-5577-8221","position":8,"is_corresponding":false},{"id":277997,"name":"Lisa M. Schilling","orcid":"0000-0002-6878-189X","position":9,"is_corresponding":false},{"id":294567,"name":"Gina M. Sequeira","orcid":"0000-0001-5906-869X","position":10,"is_corresponding":false},{"id":497788,"name":"Natalie Nokoff","orcid":"0000-0002-9190-3947","position":11,"is_corresponding":false},{"id":880925,"name":"Anna Valentine","orcid":"0000-0002-5098-789X","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T00:23:48.622830Z","pmid":"35945152","pmcid":"PMC9516032","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}