{"doi":"10.1210/clinem/dgac427","title":"Presentation, Management, and Outcomes of Urinary Bladder Paraganglioma: Results From a Multicenter Study","abstract":"CONTEXT: Urinary bladder paraganglioma (UBPGL) is rare. OBJECTIVE: We aimed to characterize the presentation and outcomes of patients diagnosed with UBPGL. METHODS: We conducted a multicenter study of consecutive patients with pathologically confirmed UBPGL evaluated between 1971 and 2021. Outcomes included repeat bladder surgery, metastases, and disease-specific mortality. RESULTS: Patients (n=110 total; n=56 [51%] women) were diagnosed with UBPGL at a median age of 50 years (interquartile range [IQR], 36-61 years). Median tumor size was 2 cm (IQR, 1-4 cm). UBPGL was diagnosed prior to biopsy in only 37 (34%), and only 69 (63%) patients had evaluation for catecholamine excess. In addition to the initial bladder surgery, 26 (25%) required multiple therapies, including repeat surgery in 10 (9%). Synchronous metastases were present in 9 (8%) patients, and 24 (22%) other patients with UBPGL developed metachronous metastases at a median of 4 years (IQR, 2-10 years) after the initial diagnosis. Development of metachronous metastases was associated with younger age (hazard ratio [HR] 0.97; 95% CI, 0.94-0.99), UBPGL size (HR 1.69; 95% CI, 1.31-2.17), and a higher degree of catecholamine excess (HR 5.48; 95% CI, 1.40-21.39). Disease-specific mortality was higher in patients with synchronous metastases (HR 20.80; 95% CI, 1.30-332.91). Choice of initial surgery, genetic association, sex, or presence of muscular involvement on pathology were not associated with development of metastases or mortality. CONCLUSIONS: Only a minority of patients were diagnosed before biopsy/surgery, reflecting need for better diagnostic strategies. All patients with UBPGL should have lifelong monitoring for development of recurrence and metastases.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2022,"id":244734,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6926,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311948,"name":"Andreas Ebbehøj","orcid":"0000-0001-7104-7824","position":1,"is_corresponding":false},{"id":879148,"name":"Hiba Obeid","orcid":null,"position":2,"is_corresponding":false},{"id":263020,"name":"Anand Vaidya","orcid":"0000-0002-0314-9252","position":3,"is_corresponding":false},{"id":311937,"name":"Tobias Else","orcid":"0000-0002-2262-0011","position":4,"is_corresponding":false},{"id":283057,"name":"Heather Wachtel","orcid":"0000-0003-3786-3638","position":5,"is_corresponding":false},{"id":878549,"name":"Ailsa Maria Main","orcid":"0000-0001-6263-0532","position":6,"is_corresponding":false},{"id":406212,"name":"Esben Søndergaard","orcid":"0000-0001-8041-6994","position":7,"is_corresponding":false},{"id":878550,"name":"Louise Lehmann Christensen","orcid":"0000-0001-6489-7054","position":8,"is_corresponding":false},{"id":311966,"name":"C. Christofer Juhlin","orcid":"0000-0002-5945-9081","position":9,"is_corresponding":false},{"id":213201,"name":"Jan Calissendorff","orcid":"0000-0003-2088-5814","position":10,"is_corresponding":false},{"id":283063,"name":"Debbie L. Cohen","orcid":"0000-0002-1325-315X","position":11,"is_corresponding":false},{"id":313140,"name":"Bonita Bennett","orcid":null,"position":12,"is_corresponding":false},{"id":270849,"name":"Marianne Andersen","orcid":"0000-0002-4603-9504","position":13,"is_corresponding":false},{"id":311951,"name":"Catharina Larsson","orcid":"0000-0003-4813-3657","position":14,"is_corresponding":false},{"id":370992,"name":"Madson Q. Almeida","orcid":"0000-0002-2957-6148","position":15,"is_corresponding":false},{"id":283064,"name":"Lauren Fishbein","orcid":"0000-0002-8151-5107","position":16,"is_corresponding":false},{"id":379550,"name":"Stephen A. Boorjian","orcid":"0000-0002-8705-6650","position":17,"is_corresponding":false},{"id":239619,"name":"William F. Young","orcid":"0000-0001-5481-4884","position":18,"is_corresponding":false},{"id":239586,"name":"Irina Bancos","orcid":"0000-0001-9332-2524","position":19,"is_corresponding":false},{"id":878548,"name":"Kai Yu","orcid":"0000-0001-8794-0318","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:23:30.364338Z","pmid":"35882219","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}