{"doi":"10.1210/clinem/dgac320","title":"Vitamin D Levels During Pregnancy Are Associated With Offspring Telomere Length: A Longitudinal Mother-Child Study","abstract":"CONTEXT: Leukocyte telomere length (LTL) is a biomarker of biological aging and is associated with metabolic diseases such as type 2 diabetes. Insufficient maternal vitamin D was associated with increased risk for many diseases and adverse later life outcomes. OBJECTIVE: This study investigates the relationship between vitamin D levels and offspring LTL at early life. METHODS: This observational, longitudinal, hospital-based cohort study included eligible mother-child pairs from the HAPO Hong Kong Field Centre, with 853 offspring at age 6.96 ± 0.44 (mean ± SD) years. LTL was measured using real-time polymerase chain reaction while serum vitamin D metabolites 25(OH)D2, 25(OH)D3, and 3-epi-25(OH)D3 were measured in maternal blood (at gestation 24-32 weeks) and cord blood by liquid chromatography-mass spectrometry. RESULTS: LTL at follow-up was significantly shorter in boys compared with girls (P < 0.001) at age 7. Childhood LTL was negatively associated with childhood BMI (β ± SE = -0.016 ± 0.007)(P = 0.02) and HOMA-IR (β ± SE = -0.065 ± 0.021)(P = 0.002). Multiple linear regression was used to evaluate the relationship between 25(OH)D and LTL, with covariate adjustments. Childhood LTL was positively correlated with total maternal 25(OH)D (0.048 ± 0.017) (P = 0.004) and maternal 3-epi-25(OH)D3 (0.05 ± 0.017) (P = 0.003), even after adjustment for covariates. A similar association was also noted for cord 3-epi-25(OH)D3 (0.037 ± 0.018) (P = 0.035) after adjustment for offspring sex and age. CONCLUSION: Our findings suggest 25(OH)D3 and 3-epi-25(OH)D3 in utero may impact on childhood LTLs, highlighting a potential link between maternal vitamin D and biological aging.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2022,"id":291044,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9455,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":973915,"name":"Feifei Cheng","orcid":"0000-0002-8541-8734","position":1,"is_corresponding":false},{"id":973916,"name":"Di Mao","orcid":"0000-0002-0215-5941","position":2,"is_corresponding":false},{"id":973917,"name":"Cadmon K.P. Lim","orcid":"0000-0001-5523-9199","position":3,"is_corresponding":false},{"id":90167,"name":"Claudia H.T. Tam","orcid":"0000-0002-9169-0013","position":4,"is_corresponding":false},{"id":731306,"name":"Chi Chiu Wang","orcid":"0000-0002-3928-7278","position":5,"is_corresponding":false},{"id":973918,"name":"Lai Yuk Yuen","orcid":"0000-0003-2249-1077","position":6,"is_corresponding":false},{"id":973919,"name":"Michael Chan","orcid":"0000-0003-1949-1666","position":7,"is_corresponding":false},{"id":744664,"name":"Chung Shun Ho","orcid":"0000-0002-3657-6445","position":8,"is_corresponding":false},{"id":820012,"name":"Mugdha V. Joglekar","orcid":"0000-0001-5346-2266","position":9,"is_corresponding":false},{"id":820016,"name":"Anandwardhan A. Hardikar","orcid":"0000-0001-5587-2090","position":10,"is_corresponding":false},{"id":447656,"name":"Alicia J. Jenkins","orcid":"0000-0003-0583-3717","position":11,"is_corresponding":false},{"id":331144,"name":"Boyd E. Metzger","orcid":"0000-0002-6503-1962","position":12,"is_corresponding":false},{"id":331146,"name":"William L. Lowe","orcid":"0000-0001-9467-3422","position":13,"is_corresponding":false},{"id":846554,"name":"Wing Hung Tam","orcid":"0000-0003-1189-740X","position":14,"is_corresponding":false},{"id":1157,"name":"Ronald C.W.","orcid":"0000-0002-1227-803X","position":15,"is_corresponding":false},{"id":973914,"name":"Kwun Kiu Wong","orcid":"0000-0001-6378-3434","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:30:34.502076Z","pmid":"35588001","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}